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Antiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma 鈴木, 健太 スズキ, ケンタ Suzuki, Kenta open access Copyright © 2023, The Author(s) This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer Cell biology Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma of the head and neck. In this study, we examined the effects of D-allose on the proliferation of human glioblastoma (GBM) cell lines (i.e., U251MG and U87MG) in vitro and in vivo and the underlying mechanisms. D-allose treatment inhibited the proliferation of U251MG and U87MG cells in a dose-dependent manner (3–50 mM). However, D-allose treatment did not affect cell cycles or apoptosis in these cells but significantly decreased the cell division frequency in both GBM cell lines. In a subcutaneous U87MG cell xenograft model, intraperitoneal injection of D-allose (100 mg/kg/day) significantly reduced the tumor volume in 28 days. These data indicate that D-allose-induced reduction in cell proliferation is associated with a subsequent decrease in the number of cell divisions, independent of cell-cycle arrest and apoptosis. Thus, D-allose could be an attractive additive to therapeutic strategies for GBM. eng doctoral thesis P https://kagawa-u.repo.nii.ac.jp/records/2000381 https://doi.org/10.1038/s41598-023-46796-4 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10636159/ 37945736 甲第860号 博士（医学） 2024-03-24 16201 香川大学 Kagawa University https://kagawa-u.repo.nii.ac.jp/record/2000381/files/Med_A860.pdf application/pdf 2.3 MB 2024-04-12 https://kagawa-u.repo.nii.ac.jp/record/2000381/files/Med_A860_abstract.pdf application/pdf 65 KB 2024-04-12 https://kagawa-u.repo.nii.ac.jp/record/2000381/files/Med_A860_result.pdf application/pdf 84 KB 2024-04-12