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Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN Nakano-Narusawa, Yuko 中野, 裕子 ナカノ, ユウコ 成澤, 裕子 ナルサワ, ユウコ Copyright © 2014 Elsevier GmbH. All rights reserved. Chronic inflammation DHPN Lung rat tumorigenesis Quartz Strain difference Abstract Chronic inflammatory effects of single intratracheal instillation (i.t.) of quartz on rat lung tumorigenesis were examined using 4 different animal models. At first, in order to determine an appropriate dose of quartz i.t. to promote lung tumorigenesis, F344 male rats were administrated single 0, 0.5, 1, 2 or 4 mg quartz/rat after initiation by N-bis(2-hydroxypropyl) nitrosamine (DHPN). Further studies were performed to examine strain differences of the effects of chronic inflammation caused by quartz i.t. in 3 strains of rat, i.e. F344, Wistar-Hannover and SD. Each was instilled with 2 mg quartz/rat after DHPN administration and sacrificed in week 24. In addition, strain differences in generation of inflammation were determined at days 1 and 28. Finally, for determination of long-term effects period, F344 and Wistar-Hannover rats were similarly treated, but the experiment was terminated at week 52. In F344 rats, the tumor areas in DHPN treated groups showed a tendency to increase along with the dose of quartz. F344 rats demonstrated the highest and Wistar-Hannover rats the lowest sensitivity to quartz in acute and chronic phases in the 3 strains. In 52 week, in F344 rats, the multiplicity of tumors and the serum concentration of IL-6 in the group treated with DHPN and quartz were significantly increased. The present experiments indicated that chronic inflammation due to quartz instillation exerted promoting effects on lung carcinogenesis in F344, SD and Wistar-Hannover rats. The strain differences in tumor promotion appeared to correlate with inflammatory reactions to quartz and increase of IL-6. eng doctoral thesis https://kagawa-u.repo.nii.ac.jp/records/239 https://doi.org/10.1016/j.etp.2014.06.002 https://cir.nii.ac.jp/crid/1360285707114796800 25024166 https://cir.nii.ac.jp/crid/1910583860656923392 甲第607号 博士（医学） 2015-03-24 16201 香川大学 Kagawa University https://kagawa-u.repo.nii.ac.jp/record/239/files/Med_A607_abstract.pdf application/pdf 92.6 kB 2020-10-28 https://kagawa-u.repo.nii.ac.jp/record/239/files/Med_A607_result.pdf application/pdf 86.5 kB 2020-10-28