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Preliminary evidence that rivastigmine-induced inhibition of serum butyrylcholinesterase activity improves behavioral symptoms in Japanese patients with Alzheimer's disease Bando, Nobuyasu 坂東, 伸泰 バンドウ, ノブヤス open access © 2016 Japan Geriatrics Society. 香川大学に提出された博士論文が、出版社版であった。Publisher's Versionは、出版社の著作権ポリシーに基づき、リポジトリへの掲載が不可能であったため、著者のAccepted Versionをリポジトリに掲載した。 The doctoral dissertation submitted to Kagawa University was a Publisher's version. Publisher's Version posted the author 's Accepted Version in the repository as it was impossible to publish in the repository based on the copyright policy of the publisher. 12 months embargo has expired. Alzheimer's disease behavioral symptom butyrylcholinesterase cholinesterase inhibitor rivastigmine Aim To investigate whether the inhibitory rate of serum butyrylcholinesterase (BuChE) activity in Japanese patients with Alzheimer's disease is correlated with cognitive function, behavioral symptoms and caregiver burden. Methods A total of 61 patients with mild to moderately severe Alzheimer's disease who were not undergoing cholinesterase enzyme inhibitor/memantine combinatorial treatment received a rivastigmine (18 mg) patch for 24 weeks. The rate of inhibition of BuChE was correlated with scores obtained on cognitive (Mini-Mental State Examination), behavioral (the Japanese version of the modified Crichton Geriatric Behavioral Rating Scale [CGBRS] and Vitality Index [VI]) and burden (the Japanese version of Zarit Burden Inventory [ZBI]) scales; and the Clinical Global Impression of Change scale. Results The serum BuChE activity showed a significant decrease after 24 weeks compared with baseline (P < 0.001). Overall, significant effects were found in the Mini-Mental State Examination score, VI score and modified CGBRS score. We then divided patient groups into a high inhibitory rate (≥40%) group and a low inhibitory rate (<40%) group; there were significant improvements in the Mini-Mental State Examination score, VI score and modified CGBRS score in both groups. However, favorable results were seen in cooperation, restlessness and leisure on modified CGBRS subscales in the high inhibitory rate group (P < 0.001, P = 0.007, P < 0.001, respectively), and rehabilitation and other activities on VI subscales in the high inhibitory rate group (P = 0.005) compared with those in the low inhibitory rate group. Conclusions Demonstrable significant improvements in behavioral symptoms, such as low cooperation, restlessness or low activities in patients with Alzheimer's disease, were achieved on inhibition of BuChE at a rate of 40% or more. Geriatr Gerontol Int 2017; 17: 1306-1312. eng doctoral thesis P https://kagawa-u.repo.nii.ac.jp/records/327 https://doi.org/10.1111/ggi.12865 https://dl.ndl.go.jp/pid/11151097 27546156 500001077395 乙第279号 博士（医学） 2017-03-03 16201 香川大学 Kagawa University https://kagawa-u.repo.nii.ac.jp/record/327/files/Med_B279_(Accepted Version).pdf application/pdf 264.2 kB 2020-11-04 https://kagawa-u.repo.nii.ac.jp/record/327/files/Med_B279_abstract.pdf application/pdf 78.8 kB 2020-11-04 https://kagawa-u.repo.nii.ac.jp/record/327/files/Med_B279_result.pdf application/pdf 111.9 kB 2020-11-04