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Galectin-9 suppresses the proliferation of gastric cancer cells in vitro Takano, Jitsuko 髙野, 実子 タカノ, ジツコ open access Copyright © Spandidos Publications 2015. caspase-cleaved keratin 18 gastric cancer galectin-9 apoptosis microRNAs insulin-like growth factor 1 receptor angiogenesis Abstract Gastric cancer is the second-leading cause of cancer-related mortality worldwide, and the prognosis of advanced gastric cancer remains poor. Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been demonstrated to exert anti-proliferative effects on various types of cancer cells. The aim of our present study was to evaluate the effects of Gal-9 on human gastric cancer cells and the expression levels of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. In our initial experiments, Gal-9 suppressed the proliferation of gastric cancer cell lines in vitro. Our data further revealed that Gal-9 increased caspase-cleaved keratin 18 (CCK18) levels in gastric cancer cells. Additionally, Gal-9 reduced the phosphorylation of vascular endothelial growth factor receptor-3 (VEGFR-3) and insulin-like growth factor-1 receptor (IGF-1R). Furthermore, miRNA expression levels were markedly altered with Gal-9 treatment in vitro. In conclusion, Gal-9 suppressed the proliferation of human gastric cancer cells by inducing apoptosis. These findings suggest that Gal-9 could be a potential therapeutic target in the treatment of gastric cancer. eng doctoral thesis P https://kagawa-u.repo.nii.ac.jp/records/391 https://doi.org/10.3892/or.2015.4452 https://dl.ndl.go.jp/pid/11337598 26717877 500001356634 甲第637号 博士（医学） 2016-03-24 16201 香川大学 Kagawa University https://kagawa-u.repo.nii.ac.jp/record/391/files/Med_A637.pdf application/pdf 5.9 MB 2020-11-09 https://kagawa-u.repo.nii.ac.jp/record/391/files/Med_A637_abstract.pdf application/pdf 423.2 kB 2020-11-09 https://kagawa-u.repo.nii.ac.jp/record/391/files/Med_A637_result.pdf application/pdf 578.0 kB 2020-11-09