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Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model Htun, Yinmon Htun, Yinmon トゥン, インモン open access Copyright © 2019, The Author(s) This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Abstract Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H2) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three groups: hypoxic-ischaemic insult with normothermia (NT), insult with hypothermia (TH, 33.5 ± 0.5 °C), and insult with hypothermia with H2 ventilation (TH-H2, 2.1–2.7%). H2 ventilation and TH were administered for 24 h. After ventilator weaning, neurological assessment was performed every 6 h for 5 days. On day 5, the brains of the piglets were harvested for histopathological analysis. Regarding the neurological score, the piglets in the TH-H2 group consistently had the highest score from day 2 to 5 and showed a significantly higher neurological score from day 3 compared with the NT group. Most piglets in the TH-H2 group could walk at day 3 of recovery, whereas walking ability was delayed in the two other groups. The histological results revealed that TH-H2 tended to improve the status of cortical gray matter and subcortical white matter, with a considerable reduction in cell death. In this study, the combination of TH and H2 improved short-term neurological outcomes in neonatal hypoxic-ischaemic piglets. eng doctoral thesis P https://kagawa-u.repo.nii.ac.jp/records/417 https://doi.org/10.1038/s41598-019-40674-8 https://dl.ndl.go.jp/pid/11498626 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6411734/ 30858437 500001380975 甲第730号 博士（医学） 2020-03-24 16201 香川大学 Kagawa University https://kagawa-u.repo.nii.ac.jp/record/417/files/Med_A730.pdf application/pdf 5.1 MB 2020-11-09 https://kagawa-u.repo.nii.ac.jp/record/417/files/Med_A730_abstract.pdf application/pdf 98.6 kB 2020-11-09 https://kagawa-u.repo.nii.ac.jp/record/417/files/Med_A730_result.pdf application/pdf 79.6 kB 2020-11-09