2026-03-09T02:43:58Z https://kagawa-u.repo.nii.ac.jp/oai

oai:kagawa-u.repo.nii.ac.jp:02000380 2024-10-31T08:01:30Z 13:40

Predictive value of local control by 4’-[methyl-11C]-thiotymidine PET volume parameters in p16-negative oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma 大内, 陽平 オオウチ, ヨウヘイ Ouchi, Yohei [11C]4DST PET head and neck carcinoma proliferative tumor volume relapse-free survival total lesion proliferation 香川大学 Kagawa University 博士（医学） Purpose: We investigated the potential of baseline 4'-[methyl- 11 C]-thiothymidine ([ 11 C]4DST) PET for predicting loco-regional control of head and neck squamous cell carcinoma (HNSCC). Methods: A retrospective analysis was performed using volumetric parameters, such as SUVmax, proliferative tumor volume (PTV), and total lesion proliferation (TLP), of pretreatment [ 11 C]4DST PET for 91 patients with HNSCC with primary lesions in the oral cavity, hypopharynx, supraglottis, and oropharynx, which included p16-negative patients. PTV and TLP were calculated for primary lesions and metastatic lymph nodes combined. We examined the association among the parameters and relapse-free survival and whether case selection focused on biological characteristics improved the accuracy of prognosis prediction. Results: The area under the curves (AUCs) using PTV and TLP were high for the oropharyngeal/hypopharyngeal/supraglottis groups (0.91 and 0.87, respectively), whereas that of SUVmax was 0.66 ( P < 0.01). On the other hand, the oral group had lower AUCs for PTV and TLP (0.72 and 0.77, respectively). When all cases were examined, the AUCs using PTV and TLP were 0.84 and 0.83, respectively. Conclusion: Baseline [ 11 C]4DST PET/CT volume-based parameters can provide important prognostic information with p16-negative oropharyngeal, hypopharyngeal, and supraglottic cancer patients. doctoral thesis 2024-03-24 P application/pdf application/pdf application/pdf 甲第859号 https://kagawa-u.repo.nii.ac.jp/record/2000380/files/Med_A859.pdf https://kagawa-u.repo.nii.ac.jp/record/2000380/files/Med_A859_abstract.pdf https://kagawa-u.repo.nii.ac.jp/record/2000380/files/Med_A859_result.pdf https://kagawa-u.repo.nii.ac.jp/records/2000380 eng https://doi.org/10.1097/mnm.0000000000001821 38247572 Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. embargoed access