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Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets
https://kagawa-u.repo.nii.ac.jp/records/11578
https://kagawa-u.repo.nii.ac.jp/records/11578736eab2a-4d4b-45b3-aa4a-451e95f1cb68
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内容の要旨 (113.6 kB)
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審査の結果の要旨 (114.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2023-02-03 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| その他（別言語等）のタイトル | ||||||||||||
| その他のタイトル | 新生児豚において、低酸素虚血負荷後、蘇生中の脳循環反応は負荷後5日目の脳障害を反映する | |||||||||||
| 言語 | ja | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
中尾, 泰浩
× 中尾, 泰浩
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Perinatal hypoxic-ischemic brain injury of neonates remains a significant problem worldwide. During the resuscitation period, changes in cerebral hemoglobin oxygen saturation (ScO2) have been identified by near-infrared spectroscopy (NIRS). However, in asphyxiated neonates, the relationship between these changes and brain injury is not known. Three-wavelength near-infrared time-resolved spectroscopy, an advanced technology for NIRS, allows for the estimation of ScO2 and cerebral blood volume (CBV). Here, we studied changes in ScO2 and CBV during the resuscitation period after hypoxic-ischemic insult and the relationship between these changes after insult and histopathological brain injuries on day 5 after insult using an asphyxiated piglet model. Of 36 newborn piglets subjected to hypoxic-ischemic insult, 29 were analyzed. ScO2 and CBV were measured 0, 5, 10, 15, and 30 min after the insult. Brain tissue was histologically evaluated on day 5. ScO2 and CBV increased immediately after the insult, reached a peak, and then maintained a consistent value. The increase in CBV 5 to 30 min after the insult was significantly correlated with histopathological injury scores. However, there was no correlation with ScO2. In conclusion, an increase in CBV within 30 min after hypoxic-ischemic insult reflects the histopathological brain injury on day 5 after insult in a piglet model. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 言語 | ja | |||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位授与機関 | ||||||||||||
| 識別子Scheme | kakenhi | |||||||||||
| 識別子 | 16201 | |||||||||||
| 言語 | ja | |||||||||||
| 機関名 | 香川大学 | |||||||||||
| 言語 | en | |||||||||||
| 機関名 | Kagawa University | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2022-12-27 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第818号 | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | © 2022. The Author(s). | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | This study was financially supported by JSPS KAKENHI Grants-in-Aid (Nos. 16K10092, 19K08253, 19K08349, and 22K07822), Kagawa University Faculty of Medicine School of Medicine Alumni Association Sanjukai Research Aid (R1-1), and the Foreign Student Scholarship of Honjo International Scholarship Foundation. The sponsors had no role in the study design, in the collection, analysis or interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication. | |||||||||||
| 論文ID（NAID） | ||||||||||||
| 識別子タイプ | NAID | |||||||||||
| 関連識別子 | 500001551085 | |||||||||||
| PubMed番号 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 35915296 | |||||||||||
| 関連サイト | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1038/s41598-022-16625-1 | |||||||||||
| 関連サイト | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | https://dl.ndl.go.jp/pid/12693731 | |||||||||||
| 関連サイト | ||||||||||||
| 関連タイプ | hasVersion | |||||||||||
| 識別子タイプ | URI | |||||||||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9343657/ | |||||||||||
| 助成情報 | ||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||
| 言語 | en | |||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10092/ | |||||||||||
| 研究課題番号 | 16K10092 | |||||||||||
| 研究課題名 | ヒトの生後早期における抗酸化作用を有するビリルビンと脳酸素消費率の変動の関連性 | |||||||||||
| 言語 | ja | |||||||||||
| 研究課題名 | Relationship between hyperbilirubinemia and cerebral oxygen metabolism in newborn infants | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||
| 言語 | en | |||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08253/ | |||||||||||
| 研究課題番号 | 19K08253 | |||||||||||
| 研究課題名 | 水素ガス吸入を用いた新規新生児蘇生法の開発 | |||||||||||
| 言語 | ja | |||||||||||
| 研究課題名 | New therapy for neonatal resuscitation using hydrogen gas | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||
| 言語 | en | |||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08349/ | |||||||||||
| 研究課題番号 | 19K08349 | |||||||||||
| 研究課題名 | 新生児における脳循環、酸素代謝状態に基づく輸血基準作成の為の基礎的検討 | |||||||||||
| 言語 | ja | |||||||||||
| 助成情報 | ||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||
| 言語 | en | |||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07822/ | |||||||||||
| 研究課題番号 | 22K07822 | |||||||||||
| 研究課題名 | 新規の近赤外光時間分解測定を用いた新生児の脳浮腫評価 | |||||||||||
| 言語 | ja | |||||||||||
| 助成情報 | ||||||||||||
| 助成機関名 | 香川大学医学部医学科同窓会讃樹會 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Alumni Association Sanjukai, Kagawa University Faculty of Medicine | |||||||||||
| 言語 | en | |||||||||||
| 助成情報 | ||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100005951 | |||||||||||
| 助成機関名 | 本庄国際奨学財団 | |||||||||||
| 言語 | ja | |||||||||||
| 助成機関名 | Honjo International Scholarship Foundation | |||||||||||
| 言語 | en | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | P | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||||||||
