{"created":"2023-05-15T09:48:47.808766+00:00","id":11728,"links":{},"metadata":{"_buckets":{"deposit":"5fa3415b-629a-41f4-b67f-7f44f068138f"},"_deposit":{"created_by":11,"id":"11728","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"11728"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00011728","sets":["13:40"]},"author_link":["4116"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ダール食塩感受性高血圧ラットにおけるエサキセレノンの降圧作用と体内ナトリウムバランスとの関連性","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The nonsteroidal mineralocorticoid receptor blocker esaxerenone is effective in reducing blood pressure (BP).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Objective: In this study, we investigated esaxerenone-driven sodium homeostasis and its association with changes in BP in Dahl salt-sensitive (DSS) hypertensive rats.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: In the different experimental setups, we evaluated BP by a radiotelemetry system, and sodium homeostasis was determined by an approach of sodium intake (food intake) and excretion (urinary excretion) in DSS rats with a low-salt diet (0.3% NaCl), high-salt diet (HSD, 8% NaCl), HSD plus 0.001% esaxerenone (w/w), and HSD plus 0.05% furosemide.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: HSD-fed DSS rats showed a dramatic increase in BP with a non-dipper pattern, while esaxerenone treatment, but not furosemide, significantly reduced BP with a dipper pattern. The cumulative sodium excretion in the active period was significantly elevated in esaxerenone- and furosemide-treated rats compared with their HSD-fed counterparts. Sodium content in the skin, skinned carcass, and total body tended to be lower in esaxerenone-treated rats than in their HSD-fed counterparts, while these values were unchanged in furosemide-treated rats. Consistently, sodium balance tended to be reduced in esaxerenone-treated rats during the active period. Histological evaluation showed that esaxerenone, but not furosemide, treatment attenuated glomerulosclerosis, tubulointerstitial fibrosis, and urinary protein excretion induced by high salt loading.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: Collectively, these findings suggest that an esaxerenone treatment-induced reduction in BP and renoprotection are associated with body sodium homeostasis in salt-loaded DSS rats.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第831号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms23168915","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9408866/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"36012182","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the authors. Licensee MDPI, Basel, Switzerland.","subitem_rights_language":"en"},{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by/4.0/"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"服部, 真依","creatorNameLang":"ja"},{"creatorName":"ハットリ, マイ","creatorNameLang":"ja-Kana"},{"creatorName":"Hattori, Mai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000408411278","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000408411278"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A831.pdf","filesize":[{"value":"6.9 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/11728/files/Med_A831.pdf"},"version_id":"e291ca40-e010-43f0-8ea6-4595bc17aa1a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A831_abstract.pdf","filesize":[{"value":"83.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/11728/files/Med_A831_abstract.pdf"},"version_id":"fd17aa49-a8cf-46b4-a32f-3ea8fe0898ce"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A831_result.pdf","filesize":[{"value":"94.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/11728/files/Med_A831_result.pdf"},"version_id":"2c5ab1b2-1680-4ae6-adb5-9af7077f05a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"esaxerenone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nonsteroidal MRB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"salt-sensitive hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"body sodium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association of antihypertensive effects of esaxerenone with the internal sodium balance in Dahl salt-sensitive hypertensive rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of antihypertensive effects of esaxerenone with the internal sodium balance in Dahl salt-sensitive hypertensive rats","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-25"},"publish_date":"2023-04-25","publish_status":"0","recid":"11728","relation_version_is_last":true,"title":["Association of antihypertensive effects of esaxerenone with the internal sodium balance in Dahl salt-sensitive hypertensive rats"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:39.465998+00:00"}