{"created":"2023-05-15T09:48:48.035450+00:00","id":11733,"links":{},"metadata":{"_buckets":{"deposit":"ff0bce22-1e0e-4524-8332-df51e0c7be97"},"_deposit":{"created_by":11,"id":"11733","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"11733"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00011733","sets":["13:40"]},"author_link":["4121"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"糖尿病レシピエンドにおけるミコフェノール酸薬物体内動態の移植腎予後への影響","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mycophenolate mofetil is a key immunosuppressant that is metabolized into mycophenolic acid (MPA). The prognostic impact of MPA-focused therapeutic drug monitoring on allograft prognosis has not been determined in kidney transplant recipients with diabetes. In this study, we assessed the pharmacokinetics of MPA and allograft prognosis in recipients with diabetes. This study retrospectively analyzed 64 adult kidney transplant recipients. MPA blood concentration data (e.g., the time to the maximum concentration (Tmax), and the area under the concentration–time curve from 0 to 12 h (AUC0–12)) were collected at 3 weeks and 3 months after kidney transplantation. Of the 64 recipients, 15 had pre-existing diabetes. At 3 months after kidney transplantation, the Tmax of MPA was significantly longer in recipients with diabetes (mean (standard deviation): 2.8 (2.1) h) than in recipients without diabetes (1.9 (1.1) h, p = 0.02). However, the allograft estimated glomerular filtration rate and acute rejection rate, including borderline change, did not differ according to the diabetes status in patients with adjusted AUC0–12 of MPA within the target range. In conclusion, a longer Tmax of MPA was observed in recipients with diabetes; however, acceptable allograft prognosis was observed in kidney transplant recipients with diabetes and a sufficient AUC0–12 of MPA.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第836号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/jpm11111224","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/12864140","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8624081/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34834579","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001563298","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 by the authors. Licensee MDPI, Basel, Switzerland.","subitem_rights_language":"en"},{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by/4.0/"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"24791653","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791653/"},"subitem_award_titles":[{"subitem_award_title":"生体腎移植における尿細管老化の検出を目的としたバイオマーカー探索研究","subitem_award_title_language":"ja"},{"subitem_award_title":"An exploratory investigation of the biomarkers for senescence and arteriosclerosis in renal transplant donors and recipients","subitem_award_title_language":"en"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"18K09195","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09195/"},"subitem_award_titles":[{"subitem_award_title":"移植腎病理レジストリ構築を介した腎移植後IgA沈着症予後予測の試み","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"21K09400","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09400/"},"subitem_award_titles":[{"subitem_award_title":"移植腎老化に着目した移植腎予後予測モデル構築に関する前向き観察研究","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 英祐","creatorNameLang":"ja"},{"creatorName":"ナカムラ, エイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamura, Eisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4121","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A836.pdf","filesize":[{"value":"437.0 kB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/11733/files/Med_A836.pdf"},"version_id":"2ef6218a-55a2-4d58-a090-a316ffa24848"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A836_abstract.pdf","filesize":[{"value":"79.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/11733/files/Med_A836_abstract.pdf"},"version_id":"58da7864-523b-4973-85fc-cd597c552d74"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-25"}],"displaytype":"detail","filename":"Med_A836_result.pdf","filesize":[{"value":"116.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/11733/files/Med_A836_result.pdf"},"version_id":"c9ed0494-ee4c-41ad-8255-57d8943523d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"kidney transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mycophenolic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"therapeutic drug monitoring","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Transplant prognosis in kidney transplant recipients with diabetes under mycophenolic acid-focused therapeutic drug monitoring","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transplant prognosis in kidney transplant recipients with diabetes under mycophenolic acid-focused therapeutic drug monitoring","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-04-25"},"publish_date":"2023-04-25","publish_status":"0","recid":"11733","relation_version_is_last":true,"title":["Transplant prognosis in kidney transplant recipients with diabetes under mycophenolic acid-focused therapeutic drug monitoring"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:40.915811+00:00"}