{"created":"2023-05-15T09:41:08.594877+00:00","id":159,"links":{},"metadata":{"_buckets":{"deposit":"d4e7b953-17c5-4480-841e-79ccc2a1711d"},"_deposit":{"created_by":11,"id":"159","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"159"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000159","sets":["13:40"]},"author_link":["3149"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒドロキシクロロキンは全身性エリテマトーデスにおけるS100タンパク質の発現上昇を調節する","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-09-16"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives\nWe investigated the effect of hydroxychloroquine (HCQ) on S100A8 and S100A9 serum levels in systemic lupus erythematosus (SLE) patients with low disease activity receiving immunosuppressants.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods\nSELENA-SLEDAI, Cutaneous Lupus Erythematous Disease Area and Severity Index (CLASI) and serum levels of complement factors, anti-dsDNA antibodies, and white blood cell, lymphocyte, and platelet counts were used to evaluate disease activity, cutaneous disease activity, and immunological activity, respectively. Serum S100A8 and S100A9 were measured at HCQ administration and after 3 or 6 months using ELISA.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results\nS100A8 and S100A9 serum levels were elevated at baseline and the magnitude of decrease from baseline at 3 and 6 months after HCQ administration was greater in patients with renal involvement than in those without (baseline: S100A8, p = 0.034; S100A9, p = 0.0084; decrease: S100A8, p = 0.049; S100A9, p = 0.023). S100 modulation was observed in patients with (n = 17; S100A8, p = 0.0011; S100A9, p = 0.0002) and without renal involvement (n = 20; S100A8, p = 0.0056; S100A9, p = 0.0012), and was more apparent in patients with improved CLASI activity scores (improved: S100A8, p = 0.013; S100A9, p = 0.0032; unimproved: S100A8, p = 0.055; S100A9, p = 0.055). No associations were observed for immunological biomarkers.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion\nHCQ may improve organ involvement in SLE by modulating S100 protein levels, especially in patients with renal or skin involvement.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第293号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1177/0961203319846391","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11570359","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31068068","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001412305","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2019 SAGE Publications","subitem_rights_language":"en"},{"subitem_rights":"This is the Accepted Version of the following article: Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus; Lupus; Volume 28 Number 7 (2019) Pages: 826-833; doi: 10.1177/0961203319846391, which has been published in final form at https://doi.org/10.1177/096120331984639","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"29131"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Wakiya, Risa","creatorNameLang":"en"},{"creatorName":"脇谷, 理沙","creatorNameLang":"ja"},{"creatorName":"ワキヤ, リサ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-20"}],"displaytype":"detail","filename":"Med_B293.pdf","filesize":[{"value":"760.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/159/files/Med_B293.pdf"},"version_id":"8364c8c8-6253-4d6c-b862-fc5f688d5adc"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-20"}],"displaytype":"detail","filename":"Med_B293_abstract.pdf","filesize":[{"value":"76.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/159/files/Med_B293_abstract.pdf"},"version_id":"587099f4-e648-439e-bc7b-13c61be173bf"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-20"}],"displaytype":"detail","filename":"Med_B293_result.pdf","filesize":[{"value":"106.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/159/files/Med_B293_result.pdf"},"version_id":"12820e8f-e088-40da-a059-36122b352cef"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"S100A8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"S100A9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Systemic lupus erythematosus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydroxychloroquine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lupus nephritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-20"},"publish_date":"2020-10-20","publish_status":"0","recid":"159","relation_version_is_last":true,"title":["Hydroxychloroquine modulates elevated expression of S100 proteins in systemic lupus erythematosus"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-02-09T01:04:20.009529+00:00"}