{"created":"2023-05-15T09:41:09.722705+00:00","id":192,"links":{},"metadata":{"_buckets":{"deposit":"2692ead8-e1af-45cf-b2a2-1685401d7af3"},"_deposit":{"created_by":11,"id":"192","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"192"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000192","sets":["13:40"]},"author_link":["1624"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-12-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nThe existence of circulating tumor cells (CTCs) in patients with lung cancer has been reported. The purpose of this study was to assess whether CTCs are predictive of the pathological effects of induction chemoradiotherapy for patients with non-small cell lung cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods\nPatients who underwent induction chemoradiotherapy followed by surgery were compared with those who underwent surgery alone. Peripheral and pulmonary venous blood samples from the involved lobe were collected intraoperatively, and the number of CTCs was counted using the CellSearch™ system, an epithelial cell adhesion molecule-based immunomagnetic technique.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results\nOf the 9 patients who underwent induction therapy, 4 achieved pathological CR, 4 achieved major response, and 1 achieved minor response. All patients who underwent induction therapy and surgery alone were negative for CTCs in peripheral blood. In the induction therapy group, 4 patients showing pathological CR were negative for CTCs in pulmonary venous blood (pvCTCs) and 5 showing major/minor response were positive (mean, 57.8 cells). The numbers of CTCs in patients showing major/minor response were significantly higher than those in patients showing pathological CR (p = 0.012, Mann–Whitney U test). All 6 patients undergoing surgery alone were positive for pvCTCs (mean, 207.5 cells), showing a significant difference from those undergoing induction therapy (p = 0.038).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions\nThe existence of CTCs in pulmonary venous blood reflects pathological non-CR, and therapeutic pathological response may be predicted by pvCTC measurement.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第577号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1749-8090-8-175","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/10224375","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718657/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23856305","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500000993806","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2013 Tarumi et al.","subitem_rights_language":"en"},{"subitem_rights":"Licensee BioMed Central Ltd.","subitem_rights_language":"en"},{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by/2.0/"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"27460"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tarumi, Shintaro","creatorNameLang":"en"},{"creatorName":"垂水, 晋太郎","creatorNameLang":"ja"},{"creatorName":"タルミ, シンタロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Tarumi","familyNameLang":"en"},{"familyName":"垂水","familyNameLang":"ja"},{"familyName":"タルミ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Shintaro","givenNameLang":"en"},{"givenName":"晋太郎","givenNameLang":"ja"},{"givenName":"シンタロウ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1624","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000001646965","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000001646965"},{"nameIdentifier":"30550082","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30550082"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-21"}],"displaytype":"detail","filename":"Med_A577.pdf","filesize":[{"value":"801.5 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/192/files/Med_A577.pdf"},"version_id":"426034be-d180-426c-8e14-fff7bd86a7db"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-21"}],"displaytype":"detail","filename":"Med_A577_abstract.pdf","filesize":[{"value":"234.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/192/files/Med_A577_abstract.pdf"},"version_id":"163dc36a-2d96-4979-9b00-f14c357acee7"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-21"}],"displaytype":"detail","filename":"Med_A577_result.pdf","filesize":[{"value":"251.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/192/files/Med_A577_result.pdf"},"version_id":"b3add4ee-75ed-41f4-80d0-c78af41a0cc1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Circulating tumor cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-small cell lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Induction chemoradiotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CellSearch","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Innovative method using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Innovative method using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-12-26"},"publish_date":"2013-12-26","publish_status":"0","recid":"192","relation_version_is_last":true,"title":["Innovative method using circulating tumor cells for prediction of the effects of induction therapy on locally advanced non-small cell lung cancer"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:02:45.643734+00:00"}