{"created":"2023-07-12T04:38:35.010437+00:00","id":2000009,"links":{},"metadata":{"_buckets":{"deposit":"0b5bc4bd-2f37-4403-a74c-a9304650255f"},"_deposit":{"created_by":11,"id":"2000009","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000009"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000009","sets":["13:40"]},"author_link":["4127"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-06-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The availability of clinically applied medical materials in thoracic surgery remains insufficient, especially materials for treating tracheal defects. Herein, the potential of porcine extracellular matrix (P-ECM) as a new airway reconstruction material was explored by xenotransplanting it into a canine trachea.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: P-ECM was first transplanted into the buttocks of Narc Beagle dogs (n = 3) and its overall immuno-induced effects were evaluated. Subsequently, nine dogs underwent surgery to create a tracheal defect that was 1 × 2 cm. In group A, the P-ECM was implanted parallel to the tracheal axis (n = 3), whereas in group B the P-ECM was implanted perpendicular to the tracheal axis (n = 6). The grafts were periodically observed by bronchoscopy and evaluated postoperatively at 1 and 3 months through macroscopic and microscopic examinations. Immunosuppressants were not administered. Statistical evaluation was performed for Bronchoscopic stenosis rate, graft epithelialization rate, shrinkage rate and ECM live-implantation rate.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: No sign of P-ECM rejection was observed after its implantation in the buttocks. Bronchoscopic findings showed no improvement concerning stenosis in group A until 3 months after surgery; epithelialization of the graft site was not evident, and the ECM site appeared scarred and faded. In contrast, stenosis gradually improved in group B, with continuous epithelium within the host tissues and P-ECM. Histologically, the graft site contracted longitudinally and no epithelialization was observed in group A, whereas full epithelialization was observed on the P-ECM in group B. No sign of cartilage regeneration was confirmed in both groups. No statistically significant differences were found in bronchoscopic stenosis rate, shrinkage rate and ECM live-implantation rate, but graft epithelialization rate showed a statistically significant difference (G-A; sporadic (25%) 3, vs. G-B; full covered (100%) 3; p = 0.047).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: P-ECM can support full re-epithelialization without chondrocyte regeneration, with perpendicular implantation facilitating epithelialization of the ECM. Our results showed that our decellularized tracheal matrix holds clinical potential as a biological xenogeneic material for airway defect repair.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第839号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fsurg.2022.1089403","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877415/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"36713663","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 katou, Go, Otsuki, Yokota, Soo, Misaki, Yajima and Yokomise.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"18K08786","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08786/"},"subitem_award_titles":[{"subitem_award_title":"非抗原性ブタ気管細胞外マトリックスを用いた異種気道手術材料の開発","subitem_award_title_language":"ja"},{"subitem_award_title":"Development of heterologous airway surgical material using non-antigenic porcine tracheal extracellular matrix","subitem_award_title_language":"en"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"加藤, 歩","creatorNameLang":"ja"},{"creatorName":"カトウ, アユム","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Ayumu","creatorNameLang":"en"}],"familyNames":[{"familyName":"加藤","familyNameLang":"ja"},{"familyName":"カトウ","familyNameLang":"ja-Kana"},{"familyName":"Kato","familyNameLang":"en"}],"givenNames":[{"givenName":"歩","givenNameLang":"ja"},{"givenName":"アユム","givenNameLang":"ja-Kana"},{"givenName":"Ayumu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4127","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000860298","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000860298"},{"nameIdentifier":"00860298","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00860298"},{"nameIdentifier":"ayumukato","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/ayumukato"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-12"}],"filename":"Med_A839.pdf","filesize":[{"value":"665 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000009/files/Med_A839.pdf"},"version_id":"fe01683d-4dae-4c5a-bfc6-6151592f9833"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-12"}],"filename":"Med_A839_abstract.pdf","filesize":[{"value":"98 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000009/files/Med_A839_abstract.pdf"},"version_id":"2c32b1a2-1741-42d7-a9d1-429b25fc4e61"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-07-12"}],"filename":"Med_A839_result.pdf","filesize":[{"value":"113 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000009/files/Med_A839_result.pdf"},"version_id":"4ca013cc-785a-4392-9ea2-de7d99993b95"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"airway defect repair","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biomaterial","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"porcine trachea","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tracheal regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Perpendicular implantation of porcine trachea extracellular matrix for enhanced xenogeneic scaffold surface epithelialization in a canine model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Perpendicular implantation of porcine trachea extracellular matrix for enhanced xenogeneic scaffold surface epithelialization in a canine model","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-07-12"},"publish_date":"2023-07-12","publish_status":"0","recid":"2000009","relation_version_is_last":true,"title":["Perpendicular implantation of porcine trachea extracellular matrix for enhanced xenogeneic scaffold surface epithelialization in a canine model"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:31.693596+00:00"}