{"created":"2023-09-29T04:17:18.660812+00:00","id":2000050,"links":{},"metadata":{"_buckets":{"deposit":"81ff80d3-37a8-4deb-91a3-ae1063c43157"},"_deposit":{"created_by":11,"id":"2000050","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000050"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000050","sets":["13:40"]},"author_link":["4136"],"control_number":"2000050","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-28"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Galectin-9 (Gal-9) induces tumor cell apoptosis in lymphoma and other malignant cell types. Duodenal adenocarcinoma is a rare malignancy, and there are insufficient data to determine a standard therapeutic approach. Here, we investigated the antitumor effect of Gal-9 in HuTu-80 duodenal adenocarcinoma cells. Materials and Methods: Cell proliferation was examined in HuTu-80 cells using a Cell Counting Kit-8 assay. Cell cycle analysis, apoptosis array, and microRNA expression analysis were performed to identify the effect of Gal-9 on HuTu-80 cells. The antitumor effect of Gal-9 was also examined using xenograft mouse models. Results: Gal-9 suppressed the proliferation of HuTu-80 via blockade of the G0 to G1 cell cycle transition. This blockade was accompanied by a strong decrease in cyclin D1 and phosphorylated Rb, suggesting a G1 arrest. Additionally, Gal-9 induced apoptosis, and the expression of cleaved caspase-3 was increased in Gal-9-treated HuTu-80 cells according to the apoptosis array. MiRNA microarrays revealed that Gal-9 altered the expression of miRNAs in HuTu-80 cells. Conclusion: These data demonstrate the therapeutic potential of Gal-9 and provide molecular mechanistic insights into its antitumor effect in HuTu-80 cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第843号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.16562","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"37500141","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"restricted access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_16ec"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 寿明","creatorNameLang":"ja"},{"creatorName":"コウノ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kono, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"河野","familyNameLang":"ja"},{"familyName":"コウノ","familyNameLang":"ja-Kana"},{"familyName":"Kono","familyNameLang":"en"}],"givenNames":[{"givenName":"寿明","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4136","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-29"}],"filename":"Med_A843_abstract.pdf","filesize":[{"value":"49 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000050/files/Med_A843_abstract.pdf"},"version_id":"f28cfcc0-8e8f-42b2-ae97-5f705ee466d7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-29"}],"filename":"Med_A843_result.pdf","filesize":[{"value":"100 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000050/files/Med_A843_result.pdf"},"version_id":"6bcfaa02-360e-4e22-9065-f86af03295c7"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-31"}],"filename":"Med_A843_summary.pdf","filesize":[{"value":"342 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文の要約","objectType":"summary","url":"https://kagawa-u.repo.nii.ac.jp/record/2000050/files/Med_A843_summary.pdf"},"version_id":"d60826c3-d9ce-45e5-8f82-b9e028a3d619"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Galectin-9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"duodenal adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Antitumor Effect of Galectin-9 on Cell Proliferation and Tumor Growth of Human Duodenal Adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antitumor Effect of Galectin-9 on Cell Proliferation and Tumor Growth of Human Duodenal Adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-29"},"publish_date":"2023-09-29","publish_status":"0","recid":"2000050","relation_version_is_last":true,"title":["Antitumor Effect of Galectin-9 on Cell Proliferation and Tumor Growth of Human Duodenal Adenocarcinoma"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:30.894655+00:00"}