{"created":"2023-09-29T05:08:50.766581+00:00","id":2000051,"links":{},"metadata":{"_buckets":{"deposit":"3e029f12-0160-4ffc-addf-64b583fe9750"},"_deposit":{"created_by":11,"id":"2000051","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000051"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000051","sets":["13:40"]},"author_link":["2818"],"control_number":"2000051","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-28"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To retrospectively review locally advanced cervical cancer (CC) cases treated with three-dimensional image-guided brachytherapy (3D-IGBT) and two-dimensional (2D)-IGBT.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: Patients with Stage IB-IVa CC who underwent intracavitary irradiation between 2007 and 2021 were divided into the 3D-IGBT and 2D-IGBT groups. Local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and gastrointestinal toxicity (G3 or more) were investigated at 2/3 years post-treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Seventy-one patients in the 2D-IGBT group from 2007 to 2016 and 61 patients in the 3D-IGBT group from 2016-2021 were included in the study. The median follow-up period was 72.7 (4.6-183.9) months in the 2D-IGBT group and 30.0 (4.2-70.5) months in the 3D-IGBT group. The median age was 65.0 (40-93) years in the 2D-IGBT group and 60.0 (28-87) years in the 3D-IGBT group, but there was no difference in FIGO stage, histology, or tumor size between the groups. In treatment, the median A point dose was 56.1 (40.0-74.0) Gy in the 2D-IGBT group and 64.0 (52.0-76.8) Gy in the 3D-IGBT group (P < 0.0001), and the proportion of patients who underwent chemotherapy more than five times was 54.3% in the 2D-IGBT group and 80.8% in the 3D-IGBT group (P = 0.0004). The 2/3-year LC, DMFS, PFS, and OS rates were 87.3%/85.5%, 77.4%/65.0%, 69.9%/59.9%, and 87.9%/77.9% in the 2D-IGBT group, and 94.2%/94.2%, 81.8%/81.8%, 80.5%/80.5%, and 91.6%/83.0% in the 3D-IGBT group, respectively. A significant difference was observed in PFS (P = 0.02). There was no difference in gastrointestinal toxicity, but there were four intestinal perforations in the patients from the 3D-IGBT group, three of whom had a history of bevacizumab treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: The 2/3-year LC of the 3D-IGBT group was excellent and PFS also tended to improve. Care should be taken with concomitant use of bevacizumab after radiotherapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第844号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s11604-023-01439-6","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"37140821","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This article is published under an open access license. Please check the 'Copyright Information' section either on this page or in the PDF for details of this license and what re-use is permitted. If your intended use exceeds what is permitted by the license or if you are unable to locate the licence and re-use information, please contact the Rights and Permissions team.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"17K10481","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10481/"},"subitem_award_titles":[{"subitem_award_title":"IMRTなど高精度放射線治療に適用する呼吸停止下照射システムの開発に関する研究","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Toshifumi","creatorNameLang":"en"},{"creatorName":"木下, 敏史","creatorNameLang":"ja"},{"creatorName":"キノシタ, トシフミ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kinoshita","familyNameLang":"en"},{"familyName":"木下","familyNameLang":"ja"},{"familyName":"キノシタ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Toshifumi","givenNameLang":"en"},{"givenName":"敏史","givenNameLang":"ja"},{"givenName":"トシフミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2818","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-05-04"}],"filename":"Med_A844.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000051/files/Med_A844.pdf"},"version_id":"17d8e20f-7429-49da-bb4d-850ba72870db"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-29"}],"filename":"Med_A844_abstract.pdf","filesize":[{"value":"60 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000051/files/Med_A844_abstract.pdf"},"version_id":"1c133f4c-016d-472f-b83c-c6d66760641c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-09-29"}],"filename":"Med_A844_result.pdf","filesize":[{"value":"112 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000051/files/Med_A844_result.pdf"},"version_id":"71b3d4bf-1fe5-4f42-bbb2-151cba08ddfa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Locally advanced cervical cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CT-based 3D-IGBT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CT-based 3D-IGBT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Bavazcizumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A retrospective study of locally advanced cervical cancer cases treated with CT-based 3D-IGBT compared with 2D-IGBT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A retrospective study of locally advanced cervical cancer cases treated with CT-based 3D-IGBT compared with 2D-IGBT","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-09-29"},"publish_date":"2023-09-29","publish_status":"0","recid":"2000051","relation_version_is_last":true,"title":["A retrospective study of locally advanced cervical cancer cases treated with CT-based 3D-IGBT compared with 2D-IGBT"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:02:37.561298+00:00"}