{"created":"2023-12-27T04:17:12.051345+00:00","id":2000125,"links":{},"metadata":{"_buckets":{"deposit":"69556247-2a97-49f3-974c-b5ff354d5705"},"_deposit":{"created_by":11,"id":"2000125","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000125"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000125","sets":["13:40"]},"author_link":["4157"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-12-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aim: The microRNA miR-452-5p holds a critical role in the progression of multiple tumor formations, but there is limited understanding regarding the epithelial-mesenchymal transition (EMT) progression and its underlying mechanisms in the early-stage colorectal cancer (CRC). We aimed to explore the change in miRNA expression in early-stage CRC and examine the role of these miRNAs in CRC.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: The expression levels of miR-452-5p in tissues and cells of early-stage CRC were determined by real-time quantitative polymerase chain reaction. Additionally, the biological effects of miR-452-5p on CRC were investigated by in vitro functional experiments.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The expression levels of miR-452-5p were found increased in early-stage CRC tissue. We found that miR-452-5p promoted CRC cell proliferation but inhibited epithelial-mesenchymal transition. Furthermore, miR-452-5p promoted cell proliferation through activation of the extracellular signal-regulated kinase pathway, and inhibited cell invasion through suppression of Slug (Snail2) expression and up-regulation of E-cadherin expression.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: The expression of miR-452-5p is up-regulated in early CRC and suppresses epithelial-mesenchymal transition in CRC. These discoveries suggest that miR-452-5p has the potential to serve as a viable therapeutic target for CRC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第845号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/invivo.13295","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10500504/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"37652512","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0)","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"21K15646","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15646/"},"subitem_award_titles":[{"subitem_award_title":"早期大腸癌に特異的なmicroRNAの同定とその機能解析","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.21873/invivo.13295","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]},{"subitem_award_numbers":{"subitem_award_number":"R3-2"},"subitem_award_titles":[{"subitem_award_title":"早期大腸癌に特異的なmicroRNAの同定とその機能解析","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"香川大学医学部医学科同窓会讃樹會","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Alumni Association Sanjukai, Kagawa University Faculty of Medicine","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小山, 裕紀子","creatorNameLang":"ja"},{"creatorName":"コヤマ, ユキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Koyama, Yukiko","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A845.pdf","filesize":[{"value":"1 MB"}],"format":"application/pdf","licensetype":"license_5","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000125/files/Med_A845.pdf"},"version_id":"6223438e-f57f-48f5-ab6c-ca3742c0409b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A845_abstract.pdf","filesize":[{"value":"406 KB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000125/files/Med_A845_abstract.pdf"},"version_id":"d2abdb32-873f-42c0-8633-8a8e3908823e"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A845_result.pdf","filesize":[{"value":"109 KB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000125/files/Med_A845_result.pdf"},"version_id":"5815dcbf-588c-4d8d-a1bc-1b38a71dc49b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miR-452-5p","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial–mesenchymal transition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Role of Mir-452-5p Overexpression in Epithelial–Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Mir-452-5p Overexpression in Epithelial–Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-27"},"publish_date":"2023-12-27","publish_status":"0","recid":"2000125","relation_version_is_last":true,"title":["Role of Mir-452-5p Overexpression in Epithelial–Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-12-27T04:44:06.703949+00:00"}