{"created":"2023-12-27T05:41:34.451810+00:00","id":2000127,"links":{},"metadata":{"_buckets":{"deposit":"9bdd7c5b-61ff-4c9f-ac5b-7a0cf27c3157"},"_deposit":{"created_by":11,"id":"2000127","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000127"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000127","sets":["13:40"]},"author_link":["4159"],"control_number":"2000127","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-12-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Peritoneal dialysis (PD) is a crucial dialysis method for treating end-stage kidney disease. However, its use is restricted due to high glucose-induced peritoneal injury and hyperglycaemia, particularly in patients with diabetes mellitus. In this study, we investigated whether partially replacing d-glucose with the rare sugar d-allose could ameliorate peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid (PDF).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: Rat peritoneal mesothelial cells (RPMCs) were exposed to a medium containing d-glucose or d-glucose partially replaced with different concentrations of d-allose. Cell viability, oxidative stress and cytokine production were evaluated. Sprague-Dawley (SD) rats were administrated saline, a PDF containing 4% d-glucose (PDF-G4.0%) or a PDF containing 3.6% d-glucose and 0.4% d-allose (PDF-G3.6%/A0.4%) once a day for 4 weeks. Peritoneal injury and PD efficiency were assessed using immuno-histological staining and peritoneal equilibration test, respectively. Blood glucose levels were measured over 120 min following a single injection of saline or PDFs to 24-h fasted SD rats.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: In RPMCs, the partial replacement of d-glucose with d-allose increased cell viability and decreased oxidative stress and cytokine production compared to d-glucose alone. Despite the PDF-G3.6%/A0.4% having a lower d-glucose concentration compared to PDF-G4.0%, there were no significant changes in osmolality. When administered to SD rats, the PDF-G3.6%/A0.4% suppressed the elevation of peritoneal thickness and blood d-glucose levels induced by PDF-G4.0%, without impacting PD efficiency.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: Partial replacement of d-glucose with d-allose ameliorated peritoneal injury and hyperglycaemia induced by high concentration of d-glucose in PDF, indicating that d-allose could be a potential treatment option in PD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第847号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1177/08968608231184354","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"37525525","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The author(s) received financial support for the research, authorship, and/or publication of this article: Part of this work was supported by Translational Research Grant A from Okayama University (2020, Al03) and the Regional Innovation Ecosystems of the Ministry of Education, Culture, Sports, Science and Technology, Japan.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100012330","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"岡山大学","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Okayama University","subitem_funder_name_language":"ja"}]},{"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001700","subitem_funder_identifier_type":"Crossref Funder"},"subitem_funder_names":[{"subitem_funder_name":"文部科学省","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Ministry of Education, Culture, Sports, Science and Technology","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尾崎, 太郎","creatorNameLang":"ja"},{"creatorName":"オザキ, タロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozaki, Taro","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A847.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000127/files/Med_A847.pdf"},"version_id":"a4756163-2158-43cd-a229-00562309c6b1"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A847_abstract.pdf","filesize":[{"value":"80 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000127/files/Med_A847_abstract.pdf"},"version_id":"f899a03b-dab0-4dd2-bc01-54b4a4c71cfd"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-27"}],"filename":"Med_A847_result.pdf","filesize":[{"value":"116 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000127/files/Med_A847_result.pdf"},"version_id":"7055854f-a823-49cf-9ca1-b17e4a42708b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"d-allose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peritoneal dialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rare sugar","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Partial replacement of d-glucose with d-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Partial replacement of d-glucose with d-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-27"},"publish_date":"2023-12-27","publish_status":"0","recid":"2000127","relation_version_is_last":true,"title":["Partial replacement of d-glucose with d-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-12-27T06:37:37.501323+00:00"}