{"created":"2024-04-09T08:15:30.306478+00:00","id":2000362,"links":{},"metadata":{"_buckets":{"deposit":"19f28924-3a8d-4474-9e35-e977a9e1d0a0"},"_deposit":{"created_by":11,"id":"2000362","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000362"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000362","sets":["13:40"]},"author_link":["4207"],"control_number":"2000362","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/aim: The (pro)renin receptor [(P)RR] plays a role not only in cardiovascular and renal diseases, but also in tumorigenesis. (P)RR contributes to the activation of the Wnt/β-catenin signaling pathway, independent of the renin-angiotensin system. Accumulating evidence has shown that (P)RR is expressed in various human cancers. However, its clinical impact in lung carcinomas remains unclear. This study aimed to clarify the associations between (P)RR expression and clinical outcomes in patients with non-small cell lung carcinoma (NSCLC).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Patients and methods: We analyzed the data of 913 patients with NSCLC who underwent resection between 1999 and 2016. Tissue microarrays were constructed and the expression of (P)RR and β-catenin was investigated using immunohistochemistry. Recurrence-free probability and overall survival were analyzed using a log-rank test and Cox proportional hazards model.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: In adenocarcinomas, (P)RR down-regulation correlated significantly with high-grade tumors (p=0.026) and a higher risk of recurrence in all patients (p=0.001). Among patients with (P)RR-positive tumors, the nuclear expression of β-catenin was associated with a higher risk of recurrence (p=0.001). Multivariate analysis revealed that (P)RR down-regulation was an independent predictor of disease recurrence (p=0.031). Conversely, in squamous cell carcinoma, (P)RR was not associated with patient outcomes.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: (P)RR down-regulation is associated with a higher risk of recurrence in lung adenocarcinomas, thereby characterizing a prognostic subset within high-grade tumors.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第849号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.16772","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"38030187","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, なちの","creatorNameLang":"ja"},{"creatorName":"キムラ, ナチノ","creatorNameLang":"ja-Kana"},{"creatorName":"Kimura, Nachino","creatorNameLang":"en"}],"familyNames":[{"familyName":"木村","familyNameLang":"ja"},{"familyName":"キムラ","familyNameLang":"ja-Kana"},{"familyName":"Kimura","familyNameLang":"en"}],"givenNames":[{"givenName":"なちの","givenNameLang":"ja"},{"givenName":"ナチノ","givenNameLang":"ja-Kana"},{"givenName":"Nachino","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4207","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-06-30"}],"filename":"Med_A849.pdf","filesize":[{"value":"2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000362/files/Med_A849.pdf"},"version_id":"9800d50c-d939-4780-a006-2fb490da0615"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-09"}],"filename":"Med_A849_abstract.pdf","filesize":[{"value":"461 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000362/files/Med_A849_abstract.pdf"},"version_id":"f737d7e6-37e2-4cf4-98d3-0cbb68b020ee"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-09"}],"filename":"Med_A849_result.pdf","filesize":[{"value":"85 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000362/files/Med_A849_result.pdf"},"version_id":"f1a9ab94-0e54-484c-a287-4113c298e2b8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"(Pro)renin receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"(Pro)renin receptor down-regulation is associated with a higher risk of recurrence in lung adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"(Pro)renin receptor down-regulation is associated with a higher risk of recurrence in lung adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-09"},"publish_date":"2024-04-09","publish_status":"0","recid":"2000362","relation_version_is_last":true,"title":["(Pro)renin receptor down-regulation is associated with a higher risk of recurrence in lung adenocarcinoma"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:02:37.798724+00:00"}