{"created":"2024-04-10T01:01:56.011014+00:00","id":2000364,"links":{},"metadata":{"_buckets":{"deposit":"aa7ce3ed-1f64-4b43-9514-99b13a2db9fa"},"_deposit":{"created_by":11,"id":"2000364","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000364"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000364","sets":["13:40"]},"author_link":["4210"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: A significant number of patients experience early recurrence after surgical resection for pancreatic ductal adenocarcinoma (PDAC), negating the benefit of surgery. The present study conducted clinicopathologic and metabolomic analyses to explore the factors associated with the early recurrence of PDAC.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and methods: Patients who underwent pancreatectomy for PDAC at Kagawa University Hospital between 2011 and 2020 were enrolled. Tissue samples of PDAC and nonneoplastic pancreas were collected and frozen immediately after resection. Charged metabolites were quantified by capillary electrophoresis-mass spectrometry. Patients who relapsed within 1 year were defined as the early recurrence group.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Frozen tumor tissue and nonneoplastic pancreas were collected from 79 patients. The clinicopathologic analysis identified 11 predictive factors, including preoperative carbohydrate antigen 19-9 levels. The metabolomic analysis revealed that only hypotaurine was a significant risk factor for early recurrence. A multivariate analysis, including clinical and metabolic factors, showed that carbohydrate antigen 19-9 and hypotaurine were independent risk factors for early recurrence ( P = 0.045 and P = 0.049, respectively). The recurrence-free survival rate 1 year after surgery with both risk factors was only 25%.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: Our results suggested that tumor hypotaurine is a potential metabolite associated with early recurrence. Carbohydrate antigen 19-9 and hypotaurine showed a vital utility for predicting early recurrence.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第852号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1097/mpa.0000000000002304","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"38373081","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"長尾, 美奈","creatorNameLang":"ja"},{"creatorName":"ナガオ, ミナ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagao, ","creatorNameLang":"en"}],"familyNames":[{"familyName":"長尾","familyNameLang":"ja"},{"familyName":"ナガオ","familyNameLang":"ja-Kana"},{"familyName":"Nagao","familyNameLang":"en"}],"givenNames":[{"givenName":"美奈","givenNameLang":"ja"},{"givenName":"ミナ","givenNameLang":"ja-Kana"},{"givenName":"","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4210","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090977513","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090977513"},{"nameIdentifier":"90977513","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90977513"},{"nameIdentifier":"nagao.mina","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/nagao.mina"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-02-20"}],"filename":"Med_A852.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000364/files/Med_A852.pdf"},"version_id":"c746a186-47e7-4eb4-9507-6e81e9e06129"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-10"}],"filename":"Med_A852_abstract.pdf","filesize":[{"value":"598 KB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000364/files/Med_A852_abstract.pdf"},"version_id":"98363b6b-a2df-4932-ac69-b9360b0ac65b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-10"}],"filename":"Med_A852_result.pdf","filesize":[{"value":"110 KB"}],"format":"application/pdf","licensetype":"license_note","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000364/files/Med_A852_result.pdf"},"version_id":"f1794c44-223d-4ffa-be61-ebfc6a1c6241"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"capillary electrophoresis-mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypotaurine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PDAC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Serum carbohydrate antigen 19-9 and metabolite hypotaurine are predictive markers for early recurrence of pancreatic ductal adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum carbohydrate antigen 19-9 and metabolite hypotaurine are predictive markers for early recurrence of pancreatic ductal adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-10"},"publish_date":"2024-04-10","publish_status":"0","recid":"2000364","relation_version_is_last":true,"title":["Serum carbohydrate antigen 19-9 and metabolite hypotaurine are predictive markers for early recurrence of pancreatic ductal adenocarcinoma"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:32.399402+00:00"}