| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-07-31 |
| タイトル |
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|
タイトル |
Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
平石, 敬三
倉原, 琳
| ja |
倉原, 琳
|
| ja-Kana |
クラハラ, リン
|
| en |
Kurahara, Lin Hai
Kurahara, Hai-Lin
Kurahara, Lin
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|
Search repository
横見瀬, 裕保
呉, 哲彦
石川, かおり
横田, 直哉
藤原, 敦史
平野, 勝也
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Ophiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert antiproliferative and antitissue remodeling effects. Vascular remodeling and vasoconstriction play critical roles in the development of pulmonary hypertension (PH). The therapeutic potential of OCS for PH was investigated using rodent PH models, and cultured pulmonary artery endothelial and smooth muscle cells (PAECs and PASMCs), with a focus on the involvement of TRPM7. OCS ameliorated the development of PH, right ventricular hypertrophy and dysfunction in the monocrotaline-induced PH rats. The genetic knockout of TRPM7 attenuated the development of PH in mice with monocrotaline pyrrole-induced PH. TRPM7 was associated with medial hypertrophy and the plexiform lesions in rats and humans with PH. OCS suppressed proliferation of PASMCs derived from the PH patients. Ethanol extracts of OCS inhibited TRPM7-like current, TGF-β2-induced endothelial-mesenchymal transition, IL-6-induced STAT3 phosphorylation, and PDGF-induced Akt phosphorylation in PAECs or PASMCs. These inhibitory effects were recapitulated by either siRNA-mediated TRPM7 knockdown or treatment with TRPM7 antagonist FTY-720. OCS and FTY-720 induced vasorelaxation in the isolated normal human pulmonary artery. As a result, the present study proposes the therapeutic potential of OCS for the treatment of PH. The inhibition of TRPM7 is suggested to underlie the therapeutic effect of OCS. |
|
言語 |
en |
| bibliographic_information |
en : Translational research
巻 233,
p. 127-143,
発行日 2021-03-07
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| 出版者 |
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|
出版者 |
Elsevier |
|
言語 |
en |
| item_10001_source_id_9 |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1878-1810 |
| item_10001_source_id_11 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12796875 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2021 The Author(s). Published by Elsevier Inc. |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This is an open access article under the CC BY license. |
| item_10001_relation_13 |
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|
識別子タイプ |
PMID |
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関連識別子 |
33691194 |
| 関連サイト |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.trsl.2021.03.004 |
| 関連サイト |
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|
関連タイプ |
hasVersion |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9225677/ |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://doi.org/10.1016/j.trsl.2021.03.004
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