{"created":"2024-07-31T06:12:18.930243+00:00","id":2000492,"links":{},"metadata":{"_buckets":{"deposit":"83b1476a-ac14-45fa-8653-83eb42f4ec09"},"_deposit":{"created_by":50,"id":"2000492","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000492"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000492","sets":["2:1720746067615:1722393749465"]},"author_link":["1762","4334","4321"],"control_number":"2000492","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"25","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"香川産科婦人科雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Kagawa journal of obstetrics and gynecology : official journal of the Kagawa Society of Obstetrics and Gynecology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"遺伝性血管性浮腫（hereditary angioedema : HAE）は補体第一成分阻害因子（C1-inhibitor : C1-INH）の先天的異常によってブラジキニン産生が亢進し、血管透過性が亢進することで全身に局所的な発作性の浮腫を生じる遺伝性疾患である。顔面や口唇、四肢に限局性の浮腫を呈し、また腸管浮腫では急性腹痛、喉頭浮腫では呼吸困難や窒息を来しうる、有病率5万人に1人の稀な疾患として知られている。症例は31歳女性、5妊2産。22歳頃より反復する浮腫発作を自覚していたが、受診歴なく、第2子出産後に反復する浮腫発作の増強を認めたためHAEと診断された。頻回の浮腫発作に対してアンドロゲン誘導体による長期予防を考慮されていたが、自然妊娠成立し、当院での妊娠管理となった。妊娠初期より浮腫発作が時折認められていたが、外来で妊娠管理を継続した。妊娠23週2日に急性胃腸炎による脱水症状認め、身体的ストレスが高度と判断し入院管理を行った。入院中は浮腫発作を認めず、妊娠24週0日で退院後、浮腫発作は軽快していた。妊娠29週頃より浮腫発作が再度頻回となり、妊娠31週2日にC1-INH製剤を使用し、浮腫の改善を認めた。以後、外来にて妊娠管理を継続し、分娩時にC1-INH製剤を予防的な使用にて浮腫発作は認めなかった。今回のように妊娠・分娩経過中にC1-INH製剤を使用した例はまだ少なく、また頻回の浮腫発作に対しての外来管理を継続した例も少ないため、本報告を行った。HAE合併妊娠の周産期管理の方針に関しては一定の見解が得られてはおらず、各施設に委ねられている状況であり、さらなる報告の蓄積が必要と考える。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10001_heading_23":{"attribute_name":"見出し","attribute_value_mlt":[{"subitem_heading_banner_headline":"症例報告","subitem_heading_language":"ja"},{"subitem_heading_banner_headline":"[Case report]","subitem_heading_language":"en"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"香川産科婦人科学会","subitem_publisher_language":"ja"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"40021715524","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isPartOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.med.kagawa-u.ac.jp/~perigyne/ksog/journal/pdf/bukai20.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2185-1409","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Yoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"石川","familyNameLang":"ja"},{"familyName":"イシカワ","familyNameLang":"ja-Kana"},{"familyName":"Ishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"陽子","givenNameLang":"ja"},{"givenName":"ヨウコ","givenNameLang":"ja-Kana"},{"givenName":"Yoko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4334","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000398832762","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000398832762"}]},{"creatorNames":[{"creatorName":"Ishihara, Go","creatorNameLang":"en"},{"creatorName":"石原, 剛","creatorNameLang":"ja"},{"creatorName":"イシハラ, 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Haruna","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤原","familyNameLang":"ja"},{"familyName":"フジワラ","familyNameLang":"ja-Kana"},{"familyName":"Fujiwara","familyNameLang":"en"}],"givenNames":[{"givenName":"晴菜","givenNameLang":"ja"},{"givenName":"ハルナ","givenNameLang":"ja-Kana"},{"givenName":"Haruna","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4321","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000364602268","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000364602268"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝性血管性浮腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"妊娠","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"C1インヒビター","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"hereditary angioedema","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnancy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"C1-inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"遺伝性血管性浮腫合併妊娠の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝性血管性浮腫合併妊娠の1例","subitem_title_language":"ja"},{"subitem_title":"A case of pregnancy with hereditary angioedema","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"50","path":["1722393749465"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-31"},"publish_date":"2024-07-31","publish_status":"0","recid":"2000492","relation_version_is_last":true,"title":["遺伝性血管性浮腫合併妊娠の1例"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2024-09-26T02:13:53.593314+00:00"}