{"created":"2024-08-01T05:21:36.936982+00:00","id":2000498,"links":{},"metadata":{"_buckets":{"deposit":"5d0d8c70-a60d-48d7-8cae-dd3d7c136b01"},"_deposit":{"created_by":11,"id":"2000498","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000498"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000498","sets":["2"]},"author_link":["2740","4382","4370","3931"],"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"250","bibliographicPageStart":"245","bibliographicVolumeNumber":"147","bibliographic_titles":[{"bibliographic_title":"Journal of pharmacological sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sodium/glucose cotransporter 2 (SGLT2) is a renal low-affinity high-capacity sodium/glucose cotransporter expressed in the apical membrane of the early segment of proximal tubules. SGLT2 reabsorbs filtered glucose in the kidney, and its inhibitors represent a new class of oral medications used for type 2 diabetes mellitus, which act by increasing glucose and sodium excretion in urine, thereby reducing blood glucose levels. However, clinical trials showed marked improvement of renal outcomes, even in nondiabetic kidney diseases, although the underlying mechanism of this renoprotective effect is unclear. We showed that long-term excretion of salt by the kidneys, which predisposes to osmotic diuresis and water loss, induces a systemic body response for water conservation. The energy-intensive nature of water conservation leads to a reprioritization of systemic body energy metabolism. According to current data, use of SGLT2 inhibitors may result in similar reprioritization of energy metabolism to prevent dehydration. In this review article, we discuss the beneficial effects of SGLT2 inhibition from the perspective of energy metabolism and water conservation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬理学会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"}]},"item_10001_relation_13":{"attribute_name":"item_10001_relation_13","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34507633","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2021.07.006","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.","subitem_rights_language":"en"},{"subitem_rights":"This is an open access article under the CC BY-NC-ND license.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_10001_source_id_11":{"attribute_name":"item_10001_source_id_11","attribute_value_mlt":[{"subitem_source_identifier":"AA11806667","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"item_10001_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"1347-8648","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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cotransporter 2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osmotic diuresis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Water conservation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sodium/glucose cotransporter 2 and renoprotection : From the perspective of energy regulation and water conservation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sodium/glucose cotransporter 2 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