| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-01 |
| タイトル |
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|
タイトル |
Inactivation of human norovirus by chlorous acid water, a novel chlorine-based disinfectant |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
今大路, 治之
| ja |
今大路, 治之
中山, 治之
|
| ja-Kana |
イマオオジ, ハルユキ
ナカヤマ, ハルユキ
|
| en |
Imaohji, Haruyuki
Nakayama, Haruyuki
|
|
|
Search repository
多田, 彩乃
小山, 一
桑原, 知巳
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Introduction: Human norovirus (HuNoV) is a leading cause of infectious gastroenteritis. Since HuNoV shows resistance to alcohol, chlorine-based sanitizers are applied to decontaminate the virus on environmental surfaces. Chlorous acid water (CA) has been recently approved as a novel chlorine-based disinfectant categorized as a Type 2 OTC medicine in Japan. In this study, we aimed to evaluate the capability of CA to inactivate HuNoV. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Methods: HuNoV (genogroups GII.2 and GII.4) was exposed to the test disinfectants including CA and sodium hypochlorite (NaClO), and the residual RNA copy was measured by reverse transcription quantitative PCR (RT-qPCR) after pretreatment with RNase. In addition, the log10 reduction of HuNoV RNA copy number by CA and NaClO was compared in the presence of bovine serum albumin (BSA), sheep red blood cells (SRBC), polypeptone, meat extract or amino acids to evaluate the stability of these disinfectants under organic-matter-rich conditions. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Results: In the absence of organic substances, CA with 200 ppm free available chlorine provided >3.0 log10 reduction in the HuNoV RNA copy number within 5 min. Even under high organic matter load (0.3% each of BSA and SRBC or 0.5% polypeptone), 200 ppm CA achieved >3.0 log10 reduction in HuNoV RNA copy number while less than 1.0 log10 reduction was observed with 1,000 ppm sodium hypochlorite (NaClO) in the presence of 0.5% polypeptone. CA reacted with only cysteine, histidine and glutathione while NaClO reacted with all of the amino acids tested. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Conclusions: CA is an effective disinfectant to inactivate HuNoV under organic-matter-rich conditions. |
|
言語 |
en |
| bibliographic_information |
en : Journal of infection and chemotherapy
巻 28,
号 1,
p. 67-72,
発行日 2022-01
|
| 出版者 |
|
|
出版者 |
日本感染症学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Japanese Society of Chemotherapy |
|
言語 |
en |
| item_10001_source_id_9 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1437-7780 |
| item_10001_source_id_11 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11627318 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
This is an open access article under the CC BY-NC-ND license. |
| item_10001_relation_13 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
34635450 |
| 関連サイト |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jiac.2021.10.001 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chlorous acid water |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Human norovirus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Disinfection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Organic substances |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
qPCR |
https://doi.org/10.1016/j.jiac.2021.10.001
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