| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-08-02 |
| タイトル |
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|
タイトル |
Photodynamic diagnosis-assisted transurethral resection using oral 5-aminolevulinic acid decreases residual cancer and improves recurrence-free survival in patients with non-muscle-invasive bladder cancer |
|
言語 |
ja |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
田岡, 利宜也
松岡, 祐貴
山﨑, 真理
可児, 尚弥
本田, 智子
原田, 怜
土肥, 洋一郎
加藤, 琢磨
岡添, 誉
常森, 寛行
上田, 修史
杉元, 幹史
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: 5-aminolevulinic acid is a protoporphyrin IX precursor used for photodynamic diagnosis. We aimed to clarify the therapeutic benefits of orally administered 5-aminolevulinic acid for photodynamic diagnosis in transurethral resection for non-muscle-invasive bladder cancer in a real-world setting. |
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言語 |
en |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Methods: From January 2009 to December 2020, patients with non-muscle-invasive bladder cancer who have undergone visually complete resection by initial transurethral surgery were included. Histopathologically confirmed residual and intravesical recurrent bladder cancer was retrospectively investigated and compared with transurethral resection using photodynamic diagnosis and conventional white light. |
|
言語 |
en |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Results: One hundred and fifteen patients who underwent photodynamic diagnosis-transurethral resection were compared with 346 patients who underwent white light-transurethral resection. The second transurethral resection revealed that the proportion of residual T1 and Ta bladder cancer was lower in the photodynamic diagnosis group than in the white light group (10.3% vs. 33.8%, P = 0.001). Additionally, the proportion of intravesical recurrence was lower in the photodynamic diagnosis group than in the white light group (9.6% vs. 41.9%, P < 0.001). Using 5-aminolevulinic acid-photodynamic diagnosis during transurethral resection of bladder tumor improved the cumulative intravesical recurrence-free survival (log-rank test: P < 0.001). Furthermore, multivariate analyses indicated that not using 5-aminolevulinic acid-photodynamic diagnosis was an independent predictive factor for residual bladder cancer (odds ratio, 6.16; 95% confidence interval, 2.10-18.0; P < 0.001) and intravesical recurrence (hazard ratio, 2.01; 95% confidence interval, 1.05-3.83, P = 0.034). |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Conclusions: Introducing 5-aminolevulinic acid-photodynamic diagnosis into transurethral resection reduces residual bladder cancer and improves the cumulative intravesical recurrence-free survival in patients with non-muscle-invasive bladder cancer, indicating its possible therapeutic benefits. |
|
言語 |
en |
| bibliographic_information |
en : Photodiagnosis and photodynamic therapy
巻 38,
発行日 2022-06
|
| 出版者 |
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|
出版者 |
Elsevier |
|
言語 |
ja |
| item_10001_source_id_9 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1873-1597 |
| item_10001_source_id_11 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12796004 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2022 The Author(s). |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This is an open access article under the CC BY licene. |
| item_10001_relation_13 |
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識別子タイプ |
PMID |
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関連識別子 |
35381368 |
| 関連サイト |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1016/j.pdpdt.2022.102838 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
5-aminolevulinic acid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Photodynamic diagnosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Transurethral resection of bladder tumor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Urothelial carcinoma |
https://doi.org/10.1016/j.pdpdt.2022.102838
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