{"created":"2024-08-05T07:23:30.279856+00:00","id":2000513,"links":{},"metadata":{"_buckets":{"deposit":"0725fe44-1419-4a61-9bda-94a1a667e9a5"},"_deposit":{"created_by":11,"id":"2000513","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000513"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000513","sets":["2"]},"author_link":["4382","2740","4396","4370","3931"],"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"123","bibliographicPageStart":"115","bibliographicVolumeNumber":"149","bibliographic_titles":[{"bibliographic_title":"Journal of pharmacological sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have recently reported that the urea osmolyte-associated water conservation system is activated in fluid loss models such as high salt-induced natriuresis, renal injury-induced impaired renal concentrating ability, or skin barrier dysfunction-induced transepidermal water loss. The system consists of the interaction of multiple organs including renal urea recycling, hepato-muscular ureagenesis, and suppression of cardiovascular energy expenditure. Here, we determined the effect of pharmacological fluid loss induced by tolvaptan, a selective vasopressin V2 receptor antagonist, on water conservation. We evaluated the water conservation system in rats that consumed a control diet or a diet containing 0.1% tolvaptan. Tolvaptan increased urine volume on day 1, but this renal water loss then gradually decreased. Body water and osmolyte content were decreased by tolvaptan on day 1 but had normalized by day 7. Tolvaptan induced fluid loss on day 1, and the following restoration of body fluid on day 7 was associated with an increase in urea transporter A1-associated renal urea recycling. Tolvaptan did not affect hepato-muscular ureagenesis on day 1 and day 7, or cardiovascular energy expenditure during treatment. Thus, tolvaptan-induced fluid loss leads to activation of the water conservation system via renal urea recycling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬理学会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"}]},"item_10001_relation_13":{"attribute_name":"item_10001_relation_13","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"35641024","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2022.04.008","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 The Authors.","subitem_rights_language":"en"},{"subitem_rights":"This is an open access article under the CC BY-NC-ND license.","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_10001_source_id_11":{"attribute_name":"item_10001_source_id_11","attribute_value_mlt":[{"subitem_source_identifier":"AA12022662","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"item_10001_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"1347-8613","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4382","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090896094","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090896094"},{"nameIdentifier":"90896094","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90896094"},{"nameIdentifier":"kidoguchi_103","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/kidoguchi_103"},{"nameIdentifier":"0000-0001-8114-8952","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0001-8114-8952"}]},{"creatorNames":[{"creatorName":"Kitada, Kento","creatorNameLang":"en"},{"creatorName":"北田, 研人","creatorNameLang":"ja"},{"creatorName":"キタダ, 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ヨシヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujisawa, Yoshihide","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤澤","familyNameLang":"ja"},{"familyName":"フジサワ","familyNameLang":"ja-Kana"},{"familyName":"Fujisawa","familyNameLang":"en"}],"givenNames":[{"givenName":"良秀","givenNameLang":"ja"},{"givenName":"ヨシヒデ","givenNameLang":"ja-Kana"},{"givenName":"Yoshihide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"8000000201134","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/8000000201134"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"中野, 大介","creatorNameLang":"ja"},{"creatorName":"ナカノ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakano, Daisuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"中野","familyNameLang":"ja"},{"familyName":"ナカノ","familyNameLang":"ja-Kana"},{"familyName":"Nakano","familyNameLang":"en"}],"givenNames":[{"givenName":"大介","givenNameLang":"ja"},{"givenName":"ダイスケ","givenNameLang":"ja-Kana"},{"givenName":"Daisuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4370","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030524178","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000030524178"},{"nameIdentifier":"30524178","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30524178"},{"nameIdentifier":"daisukenakano","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/daisukenakano"},{"nameIdentifier":"0000-0002-7435-8465","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0002-7435-8465"}]},{"creatorNames":[{"creatorName":"Nishiyama, Akira","creatorNameLang":"en"},{"creatorName":"西山, 成","creatorNameLang":"ja"},{"creatorName":"ニシヤマ, アキラ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Nishiyama","familyNameLang":"en"},{"familyName":"西山","familyNameLang":"ja"},{"familyName":"ニシヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"},{"givenName":"成","givenNameLang":"ja"},{"givenName":"アキラ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3931","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010325334","nameIdentifierScheme":"CiNii 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fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urea","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiovascular energy expenditure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood pressure","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tolvaptan induces body fluid loss and subsequent water conservation in normal rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tolvaptan induces body fluid loss and subsequent water conservation in normal rats","subitem_title_language":"ja"}]},"item_type_id":"10001","owner":"11","path":["2"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-05"},"publish_date":"2024-08-05","publish_status":"0","recid":"2000513","relation_version_is_last":true,"title":["Tolvaptan induces body fluid loss and subsequent water conservation in normal rats"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-03-21T05:07:29.762273+00:00"}