| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-28 |
| タイトル |
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タイトル |
Prevalence and factors related to hypouricemia and hyperuricemia in schoolchildren : results of a large-scale cross-sectional population-based study conducted in Japan |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 識別子 |
|
|
識別子 |
https://doi.org/10.1038/s41598-022-19724-1 |
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識別子タイプ |
DOI |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
青木, 雄平
祖父江, 理
河上, 良
神田, かなえ
日下, 隆
平尾, 智広
南野, 哲男
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| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
香川県小児生活習慣病予防健診の結果をもとに、小児の血清尿酸値異常の有病率とそれに関係する因子を報告した。若年者に多く発症する運動後急性腎障害のリスクである腎性低尿酸血症の有病率が明らかになったことで今後の対策につながることが期待される。 |
|
言語 |
ja |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Hypouricemia in children including renal hypouricemia, which is a major cause of exercise-induced acute renal injury (EIAKI), is an important clinical problem, in addition to hyperuricemia. However, no large-scale studies of serum uric acid (UA) concentrations in the general pre-adolescent population have been carried out. We conducted a population-based cross-sectional study to measure the prevalences of hypouricemia and hyperuricemia and identify the associated factors. We analyzed 31,822 (16,205 boys and 15,617 girls) 9–10-year-old children who underwent pediatric health check-ups in Kagawa prefecture between 2014 and 2018. Hypouricemia and hyperuricemia were defined using serum UA concentrations of ≤ 2.0 mg/dL and ≥ 6.0 mg/dL, respectively. The prevalence of hypouricemia was 0.38% in both 9- and 10-year-old boys and girls, and was not significantly associated with age, sex, or environmental factors, including overweight. The prevalence of hyperuricemia was significantly higher in boys (2.7%) than in girls (1.9%), and was significantly associated with age, overweight, future diabetes risk, hypertriglyceridemia, low high-density lipoprotein-cholesterol, and liver damage, but not with high low-density lipoprotein cholesterol. Therefore, some pre-adolescent children in the general population in Japan showed hypouricemia. A means of identifying children with hypouricemia and lifestyle guidance measures for the prevention of EIAKI should be established. |
|
言語 |
en |
| 書誌情報 |
en : Scientific reports
巻 12,
p. 17848,
ページ数 9,
発行日 2022-10-25
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| 出版者 |
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|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2045-2322 |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| 論文ID（NAID） |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
CRID |
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関連識別子 |
https://cir.nii.ac.jp/crid/1360021394469547520 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
36284103 |
| 他の資源との関係 |
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関連タイプ |
hasVersion |
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識別子タイプ |
URI |
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関連識別子 |
https://pmc.ncbi.nlm.nih.gov/articles/PMC9596694/ |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://doi.org/10.1038/s41598-022-19724-1
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