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Objective assessment of tumor regression in post-neoadjuvant therapy resections for pancreatic ductal adenocarcinoma: comparison of multiple tumor regression grading systems
https://kagawa-u.repo.nii.ac.jp/records/2000755
https://kagawa-u.repo.nii.ac.jp/records/200075595cfec4c-1a61-48ed-aae5-5f30dd91c7e2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
https://doi.org/10.1038/s41598-020-74067-z
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2025-03-11 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Objective assessment of tumor regression in post-neoadjuvant therapy resections for pancreatic ductal adenocarcinoma: comparison of multiple tumor regression grading systems | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 識別子 | ||||||||||||||||||||||
| 識別子 | https://doi.org/10.1038/s41598-020-74067-z | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 著者 |
松田, 陽子
× 松田, 陽子
× 成澤, 裕子
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Area of residual tumor (ART) スコアという、顕微鏡の視野数に基づいたスコアを用いて、膵癌の治療効果を評価した。ARTスコアによる膵癌の治療効果判定方法は、簡便であり、有用な予後予測方法となっている。 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Neoadjuvant therapy is increasingly used to control local tumor spread and micrometastasis of pancreatic ductal adenocarcinoma (PDAC). Pathology assessments of treatment effects might predict patient outcomes after surgery. However, there are conflicting reports regarding the reproducibility and prognostic performance of commonly used tumor regression grading systems, namely College of American Pathologists (CAP) and Evans’ grading system. Further, the M.D. Anderson Cancer Center group (MDA) and the Japan Pancreas Society (JPS) have introduced other grading systems, while we recently proposed a new, simple grading system based on the area of residual tumor (ART). Herein, we aimed to assess and compare the reproducibility and prognostic performance of the modified ART grading system with those of the four grading systems using a multicenter cohort. The study cohort consisted of 97 patients with PDAC who had undergone post-neoadjuvant pancreatectomy at four hospitals. All patients were treated with gemcitabine and S-1 (GS)-based chemotherapies with/without radiation. Two pathologists individually evaluated tumor regression in accordance with the CAP, Evans’, JPS, MDA and ART grading systems, and interobserver concordance was compared between the five systems. The ART grading system was a 5-tiered system based on a number of 40× microscopic fields equivalent to the surface area of the largest ART. Furthermore, the final grades, which were either the concordant grades of the two observers or the majority grades, including those given by the third observer, were correlated with patient outcomes in each system. The interobserver concordance (kappa value) for Evans’, CAP, MDA, JPS and ART grading systems were 0.34, 0.50, 0.65, 0.33, and 0.60, respectively. Univariate analysis showed that higher ART grades were significantly associated with shorter overall survival (p = 0.001) and recurrence-free survival (p = 0.005), while the other grading systems did not show significant association with patient outcomes. The present study revealed that the ART grading system that was designed to be simple and more objective has achieved high concordance and showed a prognostic value; thus it may be most practical for assessing tumor regression in post-neoadjuvant resections for PDAC. | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 書誌情報 |
en : Scientific reports 巻 10, ページ数 12, 発行日 2020-10-26 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2045-2322 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by/4.0/ | |||||||||||||||||||||
| 権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. | |||||||||||||||||||||
| 助成情報 | ||||||||||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| プログラム情報 | 基盤研究(C) | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| プログラム情報 | Grant-in-Aid for Scientific Research (C) | |||||||||||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462127/ | |||||||||||||||||||||
| 研究課題番号 | 25462127 | |||||||||||||||||||||
| 研究課題番号タイプ | JGN | |||||||||||||||||||||
| 研究課題名 | 膵癌におけるNestinのリン酸化制御による抗腫瘍効果の検討 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 研究課題名 | Inhibition of nestin phosphorylation in pancreatic cancer cells | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 助成情報 | ||||||||||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/100018501 | |||||||||||||||||||||
| 助成機関名 | 金沢大学がん進展制御研究所 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 助成機関名 | Cancer Research Institute, Kanazawa University (KU-CRI) | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 助成情報 | ||||||||||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100008660 | |||||||||||||||||||||
| 助成機関名 | 黒住医学研究振興財団 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 助成機関名 | Kurozumi Medical Foundation | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 助成情報 | ||||||||||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/100009619 | |||||||||||||||||||||
| 助成機関名 | 日本医療研究開発機構 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 助成機関名 | Japan Agency for Medical Research and Development | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| プログラム情報 | 革新的がん医療実用化研究事業 | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| プログラム情報 | Practical Research for Innovative Cancer Control | |||||||||||||||||||||
| 研究課題番号 | 18970556 | |||||||||||||||||||||
| 研究課題名 | Borderline resectable膵癌に対する集学的治療法を用いた標準治療確立に関する研究 | |||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||||
| 論文ID（NAID） | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | CRID | |||||||||||||||||||||
| 関連識別子 | https://cir.nii.ac.jp/crid/1360853567363041920 | |||||||||||||||||||||
| PubMed番号 | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||||||
| 関連識別子 | 33106543 | |||||||||||||||||||||
| 他の資源との関係 | ||||||||||||||||||||||
| 関連タイプ | hasVersion | |||||||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||||||||
| 関連識別子 | https://pmc.ncbi.nlm.nih.gov/articles/PMC7588464/ | |||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
