| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-11 |
| タイトル |
|
|
タイトル |
Single Intratracheal Quartz Instillation Induced Chronic Inflammation and Tumourigenesis in Rat Lungs |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 識別子 |
|
|
識別子 |
https://doi.org/10.1038/s41598-020-63667-4 |
|
識別子タイプ |
DOI |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
成澤, 裕子
| en |
Nakano-Narusawa, Yuko
ナカノ, ユウコ
|
| ja |
成澤, 裕子
中野, 裕子
|
| ja-Kana |
ナルサワ, ユウコ
|
|
|
Search repository
横平, 政直
山川, けいこ
竿尾, 光祐
今井田, 克己
松田, 陽子
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
ラットへ珪肺症の原因として知られているquartz粒子を気管内投与し、肺における慢性炎症と肺発癌性の検証を行った。結果として単回の粒子への曝露であっても、持続的な慢性肺炎が起こり、将来的には発癌リスクが上昇することが示唆された。 |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Crystalline silica (quartz) is known to induce silicosis and cancer in the lungs. In the present study, we investigated the relationship between quartz-induced chronic inflammation and lung carcinogenesis in rat lungs after a single exposure to quartz. F344 rats were treated with a single intratracheal instillation (i.t.) of quartz (4 mg/rat), and control rats were treated with a single i.t. of saline. After 52 or 96 weeks, the animals were sacrificed, and the lungs and other organs were used for analyses. Quartz particles were observed in the lungs of all quartz-treated rats. According to our scoring system, the lungs of rats treated with quartz had higher scores for infiltration of lymphocytes, macrophages and neutrophils, oedema, fibrosis, and granuloma than the lungs of control rats. After 96 weeks, the quartz-treated rats had higher incidences of adenoma (85.7%) and adenocarcinoma (81.0%) than control rats (20% and 20%, respectively). Quartz-treated and control rats did not show lung neoplastic lesions at 52 weeks after treatment. The number of lung neoplastic lesions per rat positively correlated with the degree of macrophage and lymphocyte infiltration, oedema, fibrosis, and lymph follicle formation around the bronchioles. In conclusion, single i.t. of quartz may induce lung cancer in rat along with chronic inflammation. |
|
言語 |
en |
| 書誌情報 |
en : Scientific reports
巻 10,
ページ数 10,
発行日 2020-04-20
|
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2045-2322 |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by/4.0/ |
|
権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| 助成情報 |
|
|
|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子タイプURI |
https://www.crossref.org/services/funder-registry/ |
|
|
助成機関識別子 |
https://doi.org/10.13039/100015322 |
|
|
助成機関名 |
国立がん研究センター |
|
|
言語 |
ja |
|
|
助成機関名 |
National Cancer Center Japan |
|
|
言語 |
en |
|
|
言語 |
ja |
|
|
プログラム情報 |
国立がん研究センター研究開発費 |
|
|
言語 |
en |
|
|
プログラム情報 |
National Cancer Center Research and Development Fund |
| 論文ID（NAID） |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
CRID |
|
|
関連識別子 |
https://cir.nii.ac.jp/crid/1364233270838726272 |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32313071 |
| 他の資源との関係 |
|
|
関連タイプ |
hasVersion |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://pmc.ncbi.nlm.nih.gov/articles/PMC7170867/ |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://doi.org/10.1038/s41598-020-63667-4
.png)
