{"created":"2025-04-11T02:11:10.520712+00:00","id":2000860,"links":{},"metadata":{"_buckets":{"deposit":"6e4a7d8e-5583-4893-a3c0-70d6edc499fc"},"_deposit":{"created_by":50,"id":"2000860","owner":"50","owners":[50],"pid":{"revision_id":0,"type":"depid","value":"2000860"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:02000860","sets":["13:40"]},"author_link":["24931"],"control_number":"2000860","item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2025-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"item_10006_degree_grantor_9","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Molecular-level research has linked RING finger (RNF) protein family members to carcinogenesis and tumor progression. Among them, RNF128 is related to tumor progression, but reports on its association with lung cancer are few. This study aimed to clarify the unknown association between RNF128 expression and clinical outcomes in patients with lung adenocarcinoma.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: Clinical data of 545 patients with therapy-naïve lung adenocarcinoma who underwent lobectomy with systematic lymph node dissection between 1999 and 2016 were retrospectively reviewed. Histological and immunohistochemical analyses were conducted to evaluate the relationship between RNF128 expression and prognosis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Among adenocarcinoma histologic types, acinar, micropapillary, and solid tumors did not express RNF128 compared with other histologic types (p < 0.001). Patients with high RNF128 expression exhibited fewer clusters of differentiated (CD) 68+ tumor-associated macrophages (TAMs) and CD163+ TAMs. Multivariate analysis of relapse-free survival (RFS) and overall survival (OS) revealed that the lack of RNF128 expression was an independent prognostic factor for poor RFS (hazard ratio [HR] 1.60, p = 0.029) and OS (HR 1.83, p = 0.041), suggesting that RNF128 expression is a favorable prognostic factor.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: RNF128 expression may be an independent predictor of favorable outcomes in Japanese patients with untreated lung adenocarcinoma who undergo surgical resection. Further elucidation of the role of TAM-related E3 ubiquitin ligase in immune function may facilitate the development of effective immunomodulatory therapies for lung adenocarcinoma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"dissertation_number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第874号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/1759-7714.14901","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10260493/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"item_10006_relation_22","attribute_value_mlt":[{"subitem_relation_type":"isReferencedBy","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/37186218/","subitem_relation_type_select":"URI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.","subitem_rights_language":"ja"}]},"item_10006_version_type_18":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1689051968263":{"attribute_name":"助成情報","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"20K07392","subitem_award_uri":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K07392/"},"subitem_award_titles":[{"subitem_award_title":"腫瘍浸潤リンパ球と腫瘍関連マクロファージに着目した肺癌細胞の進展メカニズムの解明","subitem_award_title_language":"ja"}],"subitem_funder_identifiers":{"subitem_funder_identifier":"https://doi.org/10.13039/501100001691","subitem_funder_identifier_type":"Crossref Funder","subitem_funder_identifier_type_uri":"https://www.crossref.org/services/funder-registry/"},"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"},{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤本, 周祐","creatorNameLang":"ja"},{"creatorName":"フジモト, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Syuusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"藤本","familyNameLang":"ja"},{"familyName":"フジモト","familyNameLang":"ja-Kana"},{"familyName":"Fujimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"周祐","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Syuusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24931","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-11"}],"filename":"Med_A874.pdf","filesize":[{"value":"8.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/2000860/files/Med_A874.pdf"},"version_id":"5496a4cd-040a-4e03-9541-9b2ac2af5505"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-11"}],"filename":"Med_A874_abstract.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/2000860/files/Med_A874_abstract.pdf"},"version_id":"d7f69bd7-a07a-4372-90ae-25fc71b3d51a"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-11"}],"filename":"Med_A874_result.pdf","filesize":[{"value":"195 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/2000860/files/Med_A874_result.pdf"},"version_id":"ea7b65f4-7cd8-42d2-b2ef-715601879eda"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"carcinogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lung adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor-associated macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"RNF128 expression in lung adenocarcinoma is a favorable prognostic factor associated with decreased tumor-associated macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNF128 expression in lung adenocarcinoma is a favorable prognostic factor associated with decreased tumor-associated macrophages","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"50","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-11"},"publish_date":"2025-04-11","publish_status":"0","recid":"2000860","relation_version_is_last":true,"title":["RNF128 expression in lung adenocarcinoma is a favorable prognostic factor associated with decreased tumor-associated macrophages"],"weko_creator_id":"50","weko_shared_id":-1},"updated":"2025-05-23T02:10:58.795707+00:00"}