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High early phase hemoglobin level is associated with favorable neurological outcome in patients with severe traumatic brain injury
https://kagawa-u.repo.nii.ac.jp/records/2000895
https://kagawa-u.repo.nii.ac.jp/records/20008954924cae1-9d3c-4531-8357-310d3c267fd3
| 名前 / ファイル | ライセンス | アクション |
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本文 (3 MB)
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内容の要旨 (146 KB)
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審査の結果の要旨 (227 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2025-04-17 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | High early phase hemoglobin level is associated with favorable neurological outcome in patients with severe traumatic brain injury | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
中村, 健太郎
× 中村, 健太郎
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Background: The appropriate hemoglobin (Hb) level threshold for the early phase (i.e. from Emergency Department to ICU admission) in patients with severe traumatic brain injury (TBI) is still unknown. Therefore, we aimed to examine the association between Hb levels during the early phase and neurological outcomes in patients with severe TBI using data from the Brain Hypothermia (B-HYPO) Study Group. | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Methods: We performed a post-hoc analysis of the B-HYPO study (a prospective, multicenter, randomized controlled trial on patients with severe TBI who received either mild therapeutic hypothermia [MTH; 32.0 °C-34.0 °C] or fever control [35.5 °C-37.0 °C]). We calculated Hb levels during early phase by the formula: (admission Hb + Hb on day 1) / 2. The primary outcome was the association between during early phase Hb levels and 6-month neurological outcome after the TBI based on the Glasgow Outcome Scale scores (a measure of functional recovery defined as moderate disability or good recovery). | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Results: We reviewed data from 130 patients and found favorable neurological outcomes in 48.5% of them. We found significant differences between the favorable and unfavorable neurological outcome groups in terms of their Hb levels on admission and on day 1. But, we found no Hb level differences after day 3 (including 1 day after rewarming). Our multivariable analysis showed that Hb levels during early phase were significantly associated with favorable neurological outcomes (odds ratio, 1.387; 95% confidence interval, 1.057-1.858; P = 0.018). | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Conclusions: High early phase Hb levels are associated with favorable neurological outcomes after severe TBI. | |||||||||||||
| 言語 | en | |||||||||||||
| 学位名 | ||||||||||||||
| 言語 | ja | |||||||||||||
| 学位名 | 博士（医学） | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 識別子Scheme | kakenhi | |||||||||||||
| 識別子 | 16201 | |||||||||||||
| 言語 | ja | |||||||||||||
| 機関名 | 香川大学 | |||||||||||||
| 言語 | en | |||||||||||||
| 機関名 | Kagawa University | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2025-03-24 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 甲第879号 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | © 2020 Elsevier Inc. All rights reserved. | |||||||||||||
| item_10006_relation_22 | ||||||||||||||
| 関連タイプ | isReferencedBy | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/32507479/ | |||||||||||||
| 関連サイト | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.ajem.2020.04.065 | |||||||||||||
| 助成情報 | ||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100003478 | |||||||||||||
| 助成機関名 | 厚生労働省 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Ministry of Health, Labour and Welfare | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号 | H-14-shinkin-005 | |||||||||||||
| 助成情報 | ||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100003478 | |||||||||||||
| 助成機関名 | 厚生労働省 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Ministry of Health, Labour and Welfare | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号 | H-15-shinkin-001 | |||||||||||||
| 助成情報 | ||||||||||||||
| 識別子タイプ | Crossref Funder | |||||||||||||
| 助成機関識別子タイプURI | https://www.crossref.org/services/funder-registry/ | |||||||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100003478 | |||||||||||||
| 助成機関名 | 厚生労働省 | |||||||||||||
| 言語 | ja | |||||||||||||
| 助成機関名 | Ministry of Health, Labour and Welfare | |||||||||||||
| 言語 | en | |||||||||||||
| 研究課題番号 | H-16-shinkin-001 | |||||||||||||
| 助成情報 | ||||||||||||||
| 助成機関名 | the Japanese Human Science Association | |||||||||||||
| 言語 | en | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | P | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Glasgow Outcome Scale | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Hemoglobin | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Traumatic brain injury | |||||||||||||
