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Intravenous D‑allose administration improves blood glucose control by maintaining insulin secretion in diabetic mice with transplanted islets
https://kagawa-u.repo.nii.ac.jp/records/2000914
https://kagawa-u.repo.nii.ac.jp/records/20009145c9ec201-50ef-4d37-ad13-1a3608564bec
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本文 (6 MB)
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内容の要旨 (182 KB)
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審査の結果の要旨 (262 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2025-04-23 | |||||||||||||
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| タイトル | Intravenous D‑allose administration improves blood glucose control by maintaining insulin secretion in diabetic mice with transplanted islets | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
野毛, 誠示
× 野毛, 誠示
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Although pancreatic islet transplantation outcomes have improved, further refinements are required to extend the insulin withdrawal period. The present study examined whether intravenous D-allose administration improves insulin secretion when pancreatic islets are transplanted into type 1 diabetes model mice. Alterations in casual blood glucose levels, intraperitoneal glucose tolerance test (IPGGT) results, the number of apoptotic cells in the engrafted cells, and caspase 3, heme oxygenase 1 and nitric oxide synthase 2 (NOS2) expression in the engrafted cells were examined using the following groups of type 1 diabetic model mice with transplanted pancreatic islets: Mice that received an intravenous injection of D-allose (D-group) and those that received physiological saline as a control (C-group). The mice in the D-group had significantly lower casual blood sugar levels for a longer duration than those in the C-group. Regarding IPGGT, mice treated with D-allose exhibited smaller changes in blood glucose levels compared with untreated mice. Consequently, the incremental area under the curve of glucose in D-allose-treated mice was significantly lower than that in D-allose-untreated mice. No difference was observed in the number of engrafted cells between the groups. NOS2 mRNA expression in the engrafted cells of the D-group tended to be higher than that in the C-group. In conclusion, intravenous administration of D-allose significantly improved hyperglycemia and maintained stable blood glucose levels in type 1 diabetic mice after islet transplantation. Since there was no difference in the number of engrafted cells or apoptotic cells with or without intravenous D-allose administration, D-allose was considered to be effective in maintaining the cellular function of insulin secretion. | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | ja | |||||||||||||
| 学位名 | 博士（医学） | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 識別子Scheme | kakenhi | |||||||||||||
| 識別子 | 16201 | |||||||||||||
| 言語 | ja | |||||||||||||
| 機関名 | 香川大学 | |||||||||||||
| 言語 | en | |||||||||||||
| 機関名 | Kagawa University | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2025-03-24 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 甲第883号 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | © 2025 Noge et al. | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. | |||||||||||||
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| 関連タイプ | isReferencedBy | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/39991726/ | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.3892/etm.2025.12813 | |||||||||||||
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| 関連タイプ | hasVersion | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://pmc.ncbi.nlm.nih.gov/articles/PMC11843210/ | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | P | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_fa2ee174bc00049f | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | D-allose | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | diabetic mice | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | immunosuppressant | |||||||||||||
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| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | islets transplantation | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | type 1 diabetes mellitus | |||||||||||||
