| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-11 |
| タイトル |
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タイトル |
The PLAAT family as phospholipid-related enzymes |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 著者 |
宇山, 徹
佐々木, すみれ
Sikder, Mohammad Mamun
| ja |
Sikder, Mohammad Mamun
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| ja-Kana |
シクダル, モハマド マムン
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| en |
Sikder, Mohammad Mamun
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Search repository
岩部, 美紀
上田, 夏生
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The phospholipase A and acyltransferase (PLAAT) family is a group of structurally related proteins that are conserved among vertebrates. In humans, the family comprises five members (PLAAT1–5), which share common domain structures, and functions as phospholipase A1/A2 and acyltransferase enzymes. Regarding acyltransferase activities, PLAATs produce N-acyl-phosphatidylethanolamines, which serve as the precursor of bioactive N-acylethanolamines (NAEs). Recent evidence strongly suggests that PLAAT proteins play a crucial role in maintaining homeostasis in various organelles, such as the endoplasmic reticulum, lysosomes, mitochondria, and peroxisomes. In this process, PLAAT proteins bind to organelles and degrade them in an enzyme activity-dependent manner. Their physiological significance was revealed by the inability of PLAAT-deficient animals to degrade organelles during the maturation of the eye lens, resulting in the development of cataracts. Furthermore, the deficiency of PLAAT1, 3, and 5 in mice caused resistance to high-fat diet-induced fatty liver, the lean phenotype represented by a marked decrease in adipose tissue mass, and the exacerbation of testicular inflammation due to decreased levels of anti-inflammatory NAEs, respectively. In addition, human PLAAT3 was identified as a causative gene for lipodystrophy. We herein provide an overview of the molecular and biological properties of PLAAT proteins. |
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言語 |
en |
| 書誌情報 |
en : Progress in Lipid Research
巻 98
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| 出版者 |
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出版者 |
Elsevier |
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言語 |
en |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
0163-7827 |
| 権利 |
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言語 |
en |
|
権利情報 |
© 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| 助成情報 |
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識別子タイプ |
Crossref Funder |
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助成機関識別子タイプURI |
https://www.crossref.org/services/funder-registry/ |
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助成機関識別子 |
https://doi.org/10.13039/501100001691 |
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助成機関名 |
日本学術振興会 |
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言語 |
ja |
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助成機関名 |
Japan Society for the Promotion of Science |
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言語 |
en |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23K06380/ |
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研究課題番号 |
23K06380 |
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研究課題番号タイプ |
JGN |
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研究課題名 |
オルガネラ分解に関わる酵素PLAAT-3の脂質代謝における機能解析 |
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言語 |
ja |
| 助成情報 |
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識別子タイプ |
Crossref Funder |
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助成機関識別子タイプURI |
https://www.crossref.org/services/funder-registry/ |
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助成機関識別子 |
http://dx.doi.org/10.13039/501100011907 |
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助成機関名 |
公益財団法人三島海雲記念財団 |
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言語 |
ja |
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助成機関名 |
Mishima Kaiun Memorial Foundation |
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言語 |
en |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
https://www.sciencedirect.com/science/article/abs/pii/S016378272500013X
