| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-12 |
| タイトル |
|
|
タイトル |
Efficacy of photodynamic diagnosis for non-muscle invasive bladder cancer: Exploratory subject-based analysis in a prospective, single-arm, multicenter phase III trial |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
田岡, 利宜也
福原, 秀雄
Miyake Makito
小林, 圭太
池田, 篤史
金尾, 健人
Komai Yoshinobu
Fujiwara Ryo
Sato Yusuke
Sugimoto Mikio
Tsuzuki Toyonori
Fujimoto Kiyohide
Inoue Keiji
Oya Mototsugu
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background
This analysis utilized a subject-based analysis of data from the prospective single-arm phase III trial (jRCT2061210055) to evaluate the efficacy of photodynamic diagnosis (PDD) when 5-aminolevulinic acid hydrochloride (5-ALA) was administered 4–8 h before transurethral resection of bladder tumors (TURBT). |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Methods
This study evaluated 144 patients suspected of having non-muscle invasive bladder cancer (NMIBC), including 127 with NMIBC (38 patients had normal-to-flat-appearing cancer) and 17 without cancer. The diagnostic accuracy and clinical utility of blue light (BL) during TURBT were assessed for each patient and compared with those of white light (WL). |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Results
Subject-based analysis revealed that WL alone missed tumor lesions in 33.1 % of patients, whereas BL alone missed 3.1 % in a biopsy-based analysis (P < 0.001). WL alone failed to diagnose NMIBC in 4.7 % of patients, while BL missed 1.6 %. Adding BL to WL led to an upgrade of NMIBC risk classification in 12 of 127 patients (9.4 %), including 5 upgraded to high-risk and 4 to highest-risk categories. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Conclusion
This study is the first to demonstrate that PDD's efficacy is maintained up to 8 h after oral 5-ALA administration and indicates that PDD improves the detection rate of bladder cancer, potentially optimizing risk stratification and offering optimal additional treatment. |
|
言語 |
en |
| 書誌情報 |
en : Photodiagnosis and Photodynamic Therapy
巻 53,
発行日 2025-06
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1873-1597 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2025 The Authors. Published by Elsevier B.V. |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
https://creativecommons.org/licenses/by/4.0/ |
| PubMed番号 |
|
|
関連タイプ |
isReferencedBy |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
40086561 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Non-muscle invasive bladder cancer (NMIBC) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Photodynamic diagnosis (PDD) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
5-aminolevulinic acid (5-ALA) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
multicenter single-arm phase III trial |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
subject-based analysis |
https://www.sciencedirect.com/science/article/pii/S1572100025000833
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