| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-03 |
| タイトル |
|
|
タイトル |
Relationship between multi-pool model-based chemical exchange saturation transfer imaging, intravoxel incoherent motion MRI, and 11C-methionine uptake on PET/CT in patients with gliomas |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
高見, 康景
則兼, 敬志
木村, 成秀
三田村, 克哉
山本, 由佳
三宅, 啓介
miyoshi, mitsuharu
西山, 佳宏
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose
Magnetization transfer ratio asymmetry (MTRasym) analysis is used for chemical exchange saturation transfer (CEST) in patients with gliomas; however, this approach has limitations. CEST imaging using a multi-pool model (MPM) may allow a more detailed assessment of gliomas; however, its mechanism remains unknown. This study aimed to assess the relationship between CEST imaging by MPM, intravoxel incoherent motion (IVIM), and 11C-methionine (11C-MET) uptake on positron emission tomography/computed tomography (PET/CT) to clarify the clinical significance of CEST imaging using MPM in gliomas. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Methods
This retrospective study included 17 patients with gliomas who underwent 11C-MET PET/CT at our institution between January 2020 and January 2022. Two-dimensional axial CEST imaging was conducted using single-shot fast-spin echo acquisition at 3 T. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), f, MTRasym (3.5 ppm), parameters of MPM-based CEST imaging, and tumor-to-contralateral normal brain tissue (T/N) ratio were calculated using a region-of-interest analysis. Shapiro–Wilk test, weighted kappa coefficient, and Spearman's rank correlation coefficients were used for statistical analysis. |
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言語 |
en |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Results
Significant correlations were found between APT_T1 and T/N ratio (ρ = 0.87, p < 0.001), APT_T2 and T/N ratio (ρ = 0.47, p < 0.05), MTRasym and T/N ratio (ρ = 0.55, p < 0.01), and T2/T1 and T/N ratio (ρ = −0.36, p < 0.05). Furthermore, significant correlations were observed between APT_T1 and ADC (ρ = −0.67, p < 0.001), APT_T1 and D (ρ = −0.70, p < 0.001), APT_T2 and D* (ρ = −0.45, p < 0.05), and T2/T1 and D (ρ = 0.39, p < 0.05). |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Conclusion
These preliminary findings indicate that MPM-based CEST imaging parameters correlate with IVIM and 11C-MET uptake on PET/CT in patients with gliomas. In particular, the new parameter APT_T1 correlated more strongly with 11C-MET uptake compared to the traditional CEST parameter MTRasym. |
|
言語 |
en |
| 書誌情報 |
en : Magnetic Resonance Imaging
巻 111,
p. 148-156,
発行日 2024-09-01
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1873-5894 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| 助成情報 |
|
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|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子タイプURI |
https://www.crossref.org/services/funder-registry/ |
|
|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
|
|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K16702/ |
|
|
研究課題番号 |
20K16702 |
|
|
研究課題名 |
PETとMRIの統合評価による膠芽腫の遺伝子変異予測と予後層別化の検討 |
|
|
言語 |
ja |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
38729226 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
(11)C-methionine PET |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemical exchange saturation transfer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glioma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intravoxel incoherent motion |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Multi-pool model |
Magnetic111_148-156
