| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-09-17 |
| タイトル |
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|
タイトル |
Immunohistochemical localization of HCA1 receptor in placenta in presence of fetal growth restriction |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
香西, 亜優美
村上, 龍太
千葉, 陽一
宮井, 由美
松本, 晃一
金西, 賢治
上野, 正樹
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Introduction
Glucose metabolism produces lactate and hydrogen ions in an anaerobic environment. Fetuses with intrauterine growth restriction are considered to become progressively lactacidemic as well as hypoxic. Roles of lactate in the placenta in the presence of fetal growth restriction (FGR) remain to be clarified. |
|
言語 |
en |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Methods
Immunohistochemical localization of lactate-related substances, such as a receptor for lactate (hydroxy-carboxylic acid 1 receptor (HCA1 receptor/GPR81)), monocarboxylate transporters (MCTs) for lactate, lactate dehydrogenases (LDHs), and proteins expressed in syncytiotrophoblasts or cytotrophoblasts was examined in placentas of appropriate weight for gestational age (AGA) fetus and those showing FGR. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Results
Immunoreactivity for the HCA1 receptor was present in the cytoplasm of some trophoblasts, predominantly localized to their basal (fetus-facing) side, and was frequently colocalized with that for E-cadherin or serine peptidase inhibitor, Kunitz type 1 (SPINT1), a marker protein of cytotrophoblasts. Immunoreactivity for MCT1 and MCT4 was present on the basal and the microvillous (maternal-facing) membranes of trophoblasts in both groups, respectively. Clear immunoreactivity for LDHA and LDHB was also observed in the cytoplasm of trophoblasts, mainly localized to their basal side. However, there were no significant differences in immunohistochemically stained areas of lactate-related substances between AGA and late-onset FGR groups. On the other hand, there were correlations between coefficients of the presence of chorioamnionitis and the values of LDHB and E-cadherin. |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Discussion
Immunohistochemical localization of the HCA1 receptor was predominantly observed in the cytoplasm located on the basal side of trophoblasts, suggesting a role of lactate in human placental development, including syncytialization. |
|
言語 |
en |
| 書誌情報 |
en : Placenta
巻 154,
p. 80-87,
発行日 2024-09-01
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0143-4004 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| 助成情報 |
|
|
|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子タイプURI |
https://www.crossref.org/services/funder-registry/ |
|
|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
|
|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K16193/ |
|
|
研究課題番号 |
20K16193 |
|
|
研究課題名 |
脈絡叢上皮細胞の輸送体を介した乳酸の脳室内過剰輸送に基づく認知症増悪機序の解明 |
|
|
言語 |
ja |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
38909565 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
E-cadherin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
HCA1 receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lactate |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Placenta |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Trophoblast |
Placenta154_80-87
