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Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion
https://kagawa-u.repo.nii.ac.jp/records/2001116
https://kagawa-u.repo.nii.ac.jp/records/200111611ea75e1-edfb-43e7-b18a-c52adb4012f4
| 名前 / ファイル | ライセンス | アクション |
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本文 (8.4 MB)
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内容の要旨 (174 KB)
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審査の結果の要旨 (175 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2025-10-14 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
三好, 由希子
× 三好, 由希子
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Purpose: The purpose of this study was to evaluate the relationship between retinal blood flow and oxygen saturation during intravitreal aflibercept treatment for central retinal vein occlusion (CRVO) using OxymapT1 and laser speckle flowgraphy (LSFG). | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Methods: Thirty-two untreated patients (32 eyes) with nonischemic CRVO received monthly intravitreal aflibercept injections for 3 months followed by a pro re nata regimen; they were followed up for approximately 1 year. Central retinal thickness, retinal oxygen saturation, and retinal blood flow were measured using optical coherence tomography, OxymapT1, and LSFG, respectively. | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Results: Visual acuity (VA) and central retinal thickness (CRT; µm) significantly improved from 1 month onward in both the all-patient and nonischemic groups (VA baseline = 0.51, 0.48, 1 month = 0.30, 0.29, P = 0.049, P = 0.032; and CRT baseline = 615.0, 615.0, 1 month = 278.4, 275.0, P = 0.049, P < 0.001). Using OxymapT1, retinal venous oxygen saturation was reduced at baseline but significantly increased from 1 month after aflibercept injection and remained elevated in both groups (baseline = 34.1%, and 1 month = 41.1%, P = 0.006). Mean blur rate (MBR) remained stable overall, with a significant increase at the final visit in the nonischemic group (baseline = 22.4, and final = 27.4, P = 0.001). A significant positive correlation was found between venous oxygen saturation and MBR from 1 month after treatment onward (1 month = R = 0.538, P = 0.002). | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Conclusions: In CRVO, venous oxygen saturation and MBR were significantly correlated. | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Translational relevance: Measuring and evaluating retinal blood flow and oxygen saturation during treatment of CRVO eyes is recommended. | |||||||||||||
| 言語 | en | |||||||||||||
| 学位名 | ||||||||||||||
| 言語 | ja | |||||||||||||
| 学位名 | 博士（医学） | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 識別子Scheme | kakenhi | |||||||||||||
| 識別子 | 16201 | |||||||||||||
| 言語 | ja | |||||||||||||
| 機関名 | 香川大学 | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2025-09-25 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 甲第888号 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. | |||||||||||||
| item_10006_relation_28 | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1167/tvst.14.6.35 | |||||||||||||
| item_10006_relation_22 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 40586670 | |||||||||||||
| 関連サイト | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://pmc.ncbi.nlm.nih.gov/articles/PMC12212447/ | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | central retinal vein occlusion (CRV) | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | OxymapTl | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | retinal venous oxygen saturation | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | laser speckle flowgraphy (LSFG) | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | mean blur rate (MBR) | |||||||||||||
