{"created":"2023-05-15T09:41:10.285157+00:00","id":206,"links":{},"metadata":{"_buckets":{"deposit":"d828c50c-ea34-414c-b78d-6eb4cddb62b5"},"_deposit":{"created_by":11,"id":"206","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"206"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000206","sets":["13:40"]},"author_link":["1165"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim\nRadiofrequency ablation (RFA) is an effective standard local therapy for small hepatocellular carcinoma (HCC). However, local recurrence and/or tumor seeding after RFA remain major problems. For better understanding of underlying factors, we clarified clinicopathological features of recurrent HCC treated with RFA.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods\nThis retrospective study included 21 patients who underwent surgical resection for HCC disease recurrence after RFA. Clinicopathological findings, including patterns of recurrence, immunohistochemical expression of proliferation markers (Ki‐67 and p27Kip1) and survival outcome were assessed.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results\nThe median time interval after RFA until the diagnosis of intrahepatic and/or extrahepatic tumor progression was 12 months (range, 3–84). Radical surgical resection was attempted for intrahepatic local recurrence in 16 patients (18 lesions), for peritoneal dissemination in four, for lymph node metastases in three and for adrenal metastasis in two. In 14 of the 21 (67%) patients, the recurrent HCC were histologically diagnosed as of poorly differentiated type. Their average Ki‐67 and p27Kip1 labeling indices were significantly higher (P = 0.020) and lower (P < 0.001), respectively, compared with values for the 108 HCC surgically resected at the initial treatment. Portal involvement was significantly higher (P = 0.01) in recurrent tumors after RFA (72%) than in HCC surgically resected at the initial treatment (43%). The mortality rate of salvage surgery was 0%, with cumulative survival rates at 1 and 3 years of 58.9% and 35.7%, respectively.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion\nThe recurrent tumors after RFA have characteristics of poor differentiation degree and abnormalities in cell‐cycle regulators and are associated with aggressive vascular invasiveness.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第591号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/hepr.12223","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"23957810","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Japan Society of Hepatology","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"27474"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yamamoto, Naoki","creatorNameLang":"en"},{"creatorName":"山本, 尚樹","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ナオキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"},{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Naoki","givenNameLang":"en"},{"givenName":"尚樹","givenNameLang":"ja"},{"givenName":"ナオキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1165","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002948839","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002948839"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-27"}],"displaytype":"detail","filename":"Med_A591_abstract.pdf","filesize":[{"value":"355.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/206/files/Med_A591_abstract.pdf"},"version_id":"c4dbbf14-cb52-4be3-b0de-51fe9c45315e"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-27"}],"displaytype":"detail","filename":"Med_A591_result.pdf","filesize":[{"value":"391.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/206/files/Med_A591_result.pdf"},"version_id":"4581ab1f-9603-4f4f-a896-99d975cd0720"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiofrequency ablation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recurrence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-24"},"publish_date":"2014-03-24","publish_status":"0","recid":"206","relation_version_is_last":true,"title":["Clinicopathology of recurrent hepatocellular carcinomas after radiofrequency ablation treated with salvage surgery"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-12-26T02:09:18.875187+00:00"}