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Higher methotrexate dose is associated with lymphoproliferative disorders onset in rheumatoid arthritis patients
https://kagawa-u.repo.nii.ac.jp/records/222
https://kagawa-u.repo.nii.ac.jp/records/22215056bfc-c544-4b4f-980a-ef0a8b2cb205
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内容の要旨 (263.1 kB)
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審査の結果の要旨 (275.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2014-09-17 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Higher methotrexate dose is associated with lymphoproliferative disorders onset in rheumatoid arthritis patients | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| その他（別言語等）のタイトル | ||||||||||||||
| その他のタイトル | Association of higher methotrexate dose with lymphoproliferative disease onset in rheumatoid arthritis patients | |||||||||||||
| 著者 |
亀田, 智広
× 亀田, 智広
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and is known as MTX‐associated LPD (MTX‐LPD). Although MTX‐LPD occurs mainly in RA patients, it has not been established if MTX administration is an independent risk factor for LPD in RA patients. We examined the clinical characteristics of MTX‐LPD in Japanese RA patients and attempted to determine the risk factors for MTX‐LPD development. |
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| 言語 | en | |||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Methods We performed a nested case–control study on RA patients. We enrolled 5,753 RA patients from Kagawa, Japan. In age‐ and sex‐matched patients, we separated patients who did not develop LPD under MTX treatment (MTX non‐LPD group) from those that did (MTX‐LPD group) and conducted a comparative examination. We used multivariate analysis to determine the independent risk factors for MTX‐LPD onset. |
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| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Results There were 28 patients in the MTX‐LPD group and 125 patients in the MTX non‐LPD group. Multivariate analysis of the parameters extracted by univariate analysis revealed that the mean MTX dose was a risk factor for MTX‐LPD after adjusting for age; therefore, higher MTX dose is associated with LPD onset in RA patients. |
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| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Conclusion MTX is an independent risk factor for LPD onset in Japanese RA patients. |
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| 言語 | en | |||||||||||||
| 学位名 | ||||||||||||||
| 言語 | ja | |||||||||||||
| 学位名 | 博士（医学） | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 識別子Scheme | kakenhi | |||||||||||||
| 識別子 | 16201 | |||||||||||||
| 言語 | ja | |||||||||||||
| 機関名 | 香川大学 | |||||||||||||
| 言語 | en | |||||||||||||
| 機関名 | Kagawa University | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2014-09-17 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 乙第269号 | |||||||||||||
| 権利 | ||||||||||||||
| 言語 | en | |||||||||||||
| 権利情報 | Copyright © 2014 by the American College of Rheumatology. | |||||||||||||
| PubMed番号 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 24515570 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1002/acr.22306 | |||||||||||||
| KEID | ||||||||||||||
| 27629 | ||||||||||||||
