{"created":"2023-05-15T09:41:11.590837+00:00","id":238,"links":{},"metadata":{"_buckets":{"deposit":"ed7dca86-cd9f-42e2-a778-2e8de09c5440"},"_deposit":{"created_by":11,"id":"238","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"238"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000238","sets":["13:40"]},"author_link":["1728"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nThe purpose of this study was to investigate the effect of the renin inhibitor, aliskiren, on retinal ischemia-reperfusion injury. Retinal ischemia was induced by increasing intraocular pressure to 130 mmHg. At 7 days after ischemia, retinal damage was evaluated by measuring the retinal thickness and the number of retinal ganglion cells. Western blot was used to measure changes in the (pro)renin receptor expression. Retinal mRNA expressions of prorenin, angiotensinogen and angiotensin II type 1 receptor (AT1-R) were measured by real-time polymerase chain reaction. Rats were treated with the renin inhibitor, aliskiren. Although the number of retinal ganglion cells and the inner retinal thickness were significantly decreased at 7 days after ischemia, treatment with aliskiren significantly inhibited retinal ischemic injury. Administration of aliskiren increased mRNA expression of prorenin in the retina at 3 h after the reperfusion. The expression of the (pro)renin receptor was not changed after ischemia-reperfusion injury with or without aliskiren. Although there was an increase in the retinal expression of AT1-R at 3 h after the reperfusion, aliskiren administration suppressed this expression. A renin inhibitor attenuated subsequent ischemic damage in the rat retina via the inhibition of the prorenin-induced angiotensin generation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第606号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.exer.2014.03.011","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24709336","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2014 Elsevier Ltd. All rights reserved.","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"27645"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Ukegawa, Kaori","creatorNameLang":"en"},{"creatorName":"請川, 香里","creatorNameLang":"ja"},{"creatorName":"ウケガワ, カオリ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ukegawa","familyNameLang":"en"},{"familyName":"請川","familyNameLang":"ja"},{"familyName":"ウケガワ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Kaori","givenNameLang":"en"},{"givenName":"香里","givenNameLang":"ja"},{"givenName":"カオリ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1728","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-28"}],"displaytype":"detail","filename":"Med_A606_abstract.pdf","filesize":[{"value":"80.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/238/files/Med_A606_abstract.pdf"},"version_id":"a481e849-dacc-4eb1-9ee3-9fc0c2717b1d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-28"}],"displaytype":"detail","filename":"Med_A606_result.pdf","filesize":[{"value":"89.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/238/files/Med_A606_result.pdf"},"version_id":"1e1d14b3-7217-462b-afc5-f298c450d69d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"(pro)renin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aliskiren","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin II type 1 receptor (AT1-R)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensinogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"renin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"renin-angiotensin-aldosterone-system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"retinal ischemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-03-24"},"publish_date":"2015-03-24","publish_status":"0","recid":"238","relation_version_is_last":true,"title":["Effect of the renin inhibitor aliskiren against retinal ischemia-reperfusion injury"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:00:03.473720+00:00"}