@phdthesis{oai:kagawa-u.repo.nii.ac.jp:00000274,
 author = {Ogura, Seiko and 小椋, 聖子},
 month = {2020-10-29, 2020-10-29, 2020-10-29},
 note = {Background and objectives: Human papillomavirus (HPV) is well-known as the etiological agent for uterine cervical  cancer  or  carcinoma  of  the  oropharynx,  anus  and  vulva.  However,  the  cytopathologic  effect  of  the  HPV  infection in urinary bladder tumors has rarely been reported. The present study has been carried out to search for cytopathologic differences between HPV positive and negative cases with urothelial carcinoma., Methods: We  examined  91  specimens  from  63  patients  who  underwent  transurethral  resection  or  biopsy  for  papillary  urothelial  carcinomas  between  May  2010  and  September  2012.  p-16INK4a  expression  was  evaluated  by  immunohistochemistry. Detection of HPV DNA was carried out by in situ hybridization on formalin-fixed, paraffin-embedded  tissue  sections.  Urine  smears  were  compared  cytomorphologically  between  HPV-positive  and  HPV-negative cases., Results: p-16INK4a overexpression was detected in 29 cases (31.9%, 29/91). Of them, HPV DNA was detected in 11 cases. No significant cytopathologic differences were found in tumor cells when HPV-positive and HPV-negative cases were compared., Conclusion: HPV could be detected in urothelial carcinomas of the urinary bladder. There were no significant differences in cytopathologic features of urine smears between HPV-positive and HPV-negative cases with urothelial carcinomas.  These  results  suggest  that  HPV  infection  in  urinary  tract  does  not  add  substantial  clinically  relevant  importance to the carcinogenesis and cytomorphology of urothelial carcinomas.},
 school = {香川大学, Kagawa University},
 title = {Investigation of the Possible Cytopathological Effect of Human Papillomavirus Infection on p-16INK4a Overexpressed Urothelial Carcinomas of the Bladder in the Urine},
 year = {},
 yomi = {オグラ, セイコ}
}