{"created":"2023-05-15T09:41:13.085564+00:00","id":274,"links":{},"metadata":{"_buckets":{"deposit":"2a6f5692-7e4b-4e03-a9a5-59813a88b419"},"_deposit":{"created_by":11,"id":"274","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"274"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000274","sets":["13:40"]},"author_link":["1369"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and objectives: Human papillomavirus (HPV) is well-known as the etiological agent for uterine cervical  cancer  or  carcinoma  of  the  oropharynx,  anus  and  vulva.  However,  the  cytopathologic  effect  of  the  HPV  infection in urinary bladder tumors has rarely been reported. The present study has been carried out to search for cytopathologic differences between HPV positive and negative cases with urothelial carcinoma.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: We  examined  91  specimens  from  63  patients  who  underwent  transurethral  resection  or  biopsy  for  papillary  urothelial  carcinomas  between  May  2010  and  September  2012.  p-16INK4a  expression  was  evaluated  by  immunohistochemistry. Detection of HPV DNA was carried out by in situ hybridization on formalin-fixed, paraffin-embedded  tissue  sections.  Urine  smears  were  compared  cytomorphologically  between  HPV-positive  and  HPV-negative cases.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: p-16INK4a overexpression was detected in 29 cases (31.9%, 29/91). Of them, HPV DNA was detected in 11 cases. No significant cytopathologic differences were found in tumor cells when HPV-positive and HPV-negative cases were compared.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: HPV could be detected in urothelial carcinomas of the urinary bladder. There were no significant differences in cytopathologic features of urine smears between HPV-positive and HPV-negative cases with urothelial carcinomas.  These  results  suggest  that  HPV  infection  in  urinary  tract  does  not  add  substantial  clinically  relevant  importance to the carcinogenesis and cytomorphology of urothelial carcinomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第653号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4172/2157-7099.1000335","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/10952397","subitem_relation_type_select":"URI"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001039412","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: © 2015 Ogura s, et al.","subitem_rights_language":"en"},{"subitem_rights":"This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"27875"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Ogura, Seiko","creatorNameLang":"en"},{"creatorName":"小椋, 聖子","creatorNameLang":"ja"},{"creatorName":"オグラ, セイコ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-29"}],"displaytype":"detail","filename":"Med_A653.pdf","filesize":[{"value":"2.8 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/274/files/Med_A653_result.pdf"},"version_id":"d1a3cbc4-13d3-4fbc-8093-446adb4a8ecd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human papillomavirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urinary bladder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p16INK4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"In situhybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Investigation of the Possible Cytopathological Effect of Human Papillomavirus Infection on p-16INK4a Overexpressed Urothelial Carcinomas of the Bladder in the Urine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of the Possible Cytopathological Effect of Human Papillomavirus Infection on p-16INK4a Overexpressed Urothelial Carcinomas of the Bladder in the Urine","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-08-23"},"publish_date":"2017-08-23","publish_status":"0","recid":"274","relation_version_is_last":true,"title":["Investigation of the Possible Cytopathological Effect of Human Papillomavirus Infection on p-16INK4a Overexpressed Urothelial Carcinomas of the Bladder in the Urine"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-02-06T07:53:27.426565+00:00"}