@phdthesis{oai:kagawa-u.repo.nii.ac.jp:00000307,
 author = {Akashi, Emiko and 明石, 瑛美子},
 month = {2020-10-30, 2020-10-30, 2020-10-30},
 note = {Abstract
The incidence of esophageal adenocarcinoma (EAC) is rapidly increasing in western countries. The overall mortality of this disease remains high with a 5-year survival rate of less than 20%, despite remarkable advances in the care of patients with EAC. Galectin-9 (Gal-9) is a tandem-repeat type galectin that exerts anti-proliferative effects on various cancer cell types. The aim of the present study was to evaluate the effects of Gal-9 on human EAC cells and to assess the expression of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. Gal-9 suppressed the proliferation of the EAC cell lines OE19, OE33, SK-GT4, and OACM 5.1C. Additionally, Gal-9 treatment induced apoptosis and increased the expression levels of caspase-cleaved cytokeratin 18, activated caspase-3 and activated caspase-9. However, it did not promote cell cycle arrest by reducing cell cycle-related protein levels. Furthermore, Gal-9 increased the level of the angiogenesis-related protein interleukin-8 (IL-8) and markedly altered miRNA expression. Based on these findings, Gal-9 may be of clinical use for the treatment of EAC.},
 school = {香川大学, Kagawa University},
 title = {Effects of galectin-9 on apoptosis, cell cycle and autophagy in human esophageal adenocarcinoma cells},
 year = {},
 yomi = {アカシ, エミコ}
}