{"created":"2023-05-15T09:41:15.066723+00:00","id":319,"links":{},"metadata":{"_buckets":{"deposit":"b460ab7a-0c03-4b2a-b79c-7d47e7297d42"},"_deposit":{"created_by":11,"id":"319","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"319"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000319","sets":["13:40"]},"author_link":["71"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-05-16"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives:Calcitonin gene-related peptide (CGRP) is currently considered to be a major contributing factor in migraine headache. Botulinum toxin type A (BTXA) was found to be effective in migraine prevention.  However,  the  mechanism  of  action  in  patients  was  unknown.  Using  injection  as  in  clinical setting, the study aimed to determine whether BTXA could decrease the sensitization of the trigeminovascular  nociceptive  system  through  the  reduction  of  CGRP  action.  Methods:Adult  male  Wistar  rats  were  pretreated  with  normal  saline  solution  or  BTXA  before  KCl  application  to  induce  cortical spreading depression (CSD) or NaCl application as a control. Regional cerebral blood flow at  parietal  cortex  was  measured  for  90  min  after  KCl  or  NaCl  application.  Tissues  from  trigeminal  ganglion  (TG)  and  trigeminal  nucleus  caudalis  (TNC)  were  then  collected  for  CGRP  and  c-Fos  measurement respectively. Results: BTXA pretreatment significantly decreased the cumulative blood flow and number of hyperemic peaks induced by KCl. Numbers of CGRP positive cells at TG and c-Fos positive cells at TNC were also reduced by BTXA.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:BTXA pretreatment reduced CGRP production and release from the TG leading to lessen CSD production and persistent activation of TNC which played a major role in migraine headache.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第284号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://neurology-asia.org/articles/neuroasia-2018-23(1)-045.pdf","subitem_relation_type_select":"URI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11122967","subitem_relation_type_select":"URI"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001070082","subitem_relation_type_select":"NAID"}}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"28488"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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パタマノン","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"71","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"8000001630027","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/8000001630027"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_B284.pdf","filesize":[{"value":"998.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/319/files/Med_B284.pdf"},"version_id":"e59a65e4-c798-4966-9488-28bd2bb2f36b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_B284_abstract.pdf","filesize":[{"value":"109.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/319/files/Med_B284_abstract.pdf"},"version_id":"90585f89-f60f-45a6-82e0-4dcd2776148b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_B284_result.pdf","filesize":[{"value":"59.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/319/files/Med_B284_result.pdf"},"version_id":"f5bf9881-53b7-44e2-8d8c-25076c107101"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Migraine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcitonin gene-related peptide (CGRP)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"botulinum toxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-05"},"publish_date":"2018-07-05","publish_status":"0","recid":"319","relation_version_is_last":true,"title":["The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T07:59:56.749915+00:00"}