{"created":"2023-05-15T09:41:15.478405+00:00","id":329,"links":{},"metadata":{"_buckets":{"deposit":"68340ed4-f5bc-4dc8-8a47-2396b85bb307"},"_deposit":{"created_by":11,"id":"329","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"329"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000329","sets":["13:40"]},"author_link":["1846"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-29"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nAlthough various features of ampullary adenocarcinoma have been reported, the impact of genetic alterations and rare subtypes on clinical outcome remains unclear.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods\nWe determined the expression of proteins, including MUC1, MUC2, p53, p16, Smad/Dpc4, and β‐catenin, and genetic mutations such as KRAS, BRAF, and GNAS mutations in 69 patients with ampullary adenocarcinoma to clarify their relationships with clinicopathological findings and subtypes.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results\nKaplan–Meier survival analysis indicated that abnormal p53 labeling was significantly associated with a shorter overall survival. MUC1‐positive and MUC2‐negative expressions were significantly associated with lymphatic invasion, pancreatic invasion, lymph node metastasis, and advanced UICC stage. The KRAS mutation was significantly associated with large tumor size and pancreatic invasion. There were 35 intestinal (50%), 15 pancreatobiliary (22%), and 11 mixed subtype (16%) tumors. Patients with the mixed subtype showed significantly poor outcome. The invasiveness of the mixed subtype was similar to that of the pancreatobiliary subtype; moreover, the mixed subtype showed a high incidence of abnormal β‐catenin immunolabeling (73%).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions\nProtein expression and genetic mutation are clinically associated with the characteristics of ampullary adenocarcinoma. The mixed subtype may have a distinct tumor nature as compared to other two major subtypes.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第645号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/jso.24274","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11164126","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27132476","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001081128","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016 Wiley Periodicals, Inc.","subitem_rights_language":"en"},{"subitem_rights":"香川大学に提出された博士論文が、出版社版であった。Publisher's Versionは、出版社の著作権ポリシーに基づき、リポジトリへの掲載が不可能であったため、著者のAccepted Versionをリポジトリに掲載した。","subitem_rights_language":"ja"},{"subitem_rights":"The doctoral dissertation submitted to Kagawa University was a Publisher's version. Publisher's Version posted the author 's Accepted Version in the repository as it was impossible to publish in the repository based on the copyright policy of the publisher.","subitem_rights_language":"en"},{"subitem_rights":"12 months embargo has expired.","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"28498"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"Asano, Eisuke","creatorNameLang":"en"},{"creatorName":"浅野, 栄介","creatorNameLang":"ja"},{"creatorName":"アサノ, エイスケ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_A645(Apcepted Version).pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文　(Accepted Version)","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/329/files/Med_A645(Apcepted Version).pdf"},"version_id":"29656da3-65a5-4dee-95ce-4f1eb291ddac"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_A645_abstract.pdf","filesize":[{"value":"82.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/329/files/Med_A645_abstract.pdf"},"version_id":"89d823ba-526a-48b2-9728-c7e2a1bb7391"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-04"}],"displaytype":"detail","filename":"Med_A645_result.pdf","filesize":[{"value":"86.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/329/files/Med_A645_result.pdf"},"version_id":"551a5f6b-9030-443f-a4d5-cb7d2bf02378"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ampullary adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β‐catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pathologic subtype","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mixed type","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Phenotypic characterization and clinical outcome in ampullary adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phenotypic characterization and clinical outcome in ampullary adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-18"},"publish_date":"2018-09-18","publish_status":"0","recid":"329","relation_version_is_last":true,"title":["Phenotypic characterization and clinical outcome in ampullary adenocarcinoma"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-02-07T08:03:53.319235+00:00"}