{"created":"2023-05-15T09:41:16.007840+00:00","id":342,"links":{},"metadata":{"_buckets":{"deposit":"5947be52-9dec-4106-ac67-d578aa1cc505"},"_deposit":{"created_by":11,"id":"342","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"342"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000342","sets":["13:40"]},"author_link":["2632"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-12-26"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Selective heat shock protein 90 (Hsp90) inhibitor SNX-2112 exhibits antitumor activity in multiple cancer cell types. Here, the antitumor activity of SNX-2112 in Nara-H cells was analyzed.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Materials and Methods: Antitumor activity of SNX-2112 was assessed using a cell proliferation assay. We also examined the signalling pathways involved in SNX-2112-mediated autophagy and apoptosis of Nara-H cells by western blot and morphological analyses.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Cell proliferation assays demonstrated that SNX-2112 inhibited Nara-H cell growth. Western blotting revealed that SNX-2112 induced apoptosis and autophagy, inhibited mammalian target of rapamycin (mTOR) phosphorylation, and suppressed the mitogen-activated protein kinase (MAPK) signalling pathway. Morphological analysis confirmed that SNX-2112 induced autophagy and apoptosis.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: SNX-2112 induced autophagy and apoptosis of Nara-H cells by inhibiting mTOR and MAPK pathways. Our results support developing SNX-2112 to treat human soft tissue sarcomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第699号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.12840","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11246018","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30194165","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001323220","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"28571"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Fukuoka, Natsuko","creatorNameLang":"en"},{"creatorName":"福岡, 奈津子","creatorNameLang":"ja"},{"creatorName":"フクオカ, ナツコ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Fukuoka","familyNameLang":"en"},{"familyName":"福岡","familyNameLang":"ja"},{"familyName":"フクオカ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Natsuko","givenNameLang":"en"},{"givenName":"奈津子","givenNameLang":"ja"},{"givenName":"ナツコ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2632","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000390426984","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000390426984"},{"nameIdentifier":"30771232","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30771232"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A699.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/342/files/Med_A699.pdf"},"version_id":"6edc2dee-f418-4c69-88c4-0a5f4628152d"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A699_abstract.pdf","filesize":[{"value":"70.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/342/files/Med_A699_abstract.pdf"},"version_id":"49cb56bc-28f9-44bf-928d-6f59bdc919ff"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A699_result.pdf","filesize":[{"value":"105.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/342/files/Med_A699_result.pdf"},"version_id":"f802f748-c9f0-4bfd-a966-da28672e94be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SNX-2112","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"undifferentiated pleomorphic sarcoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-01-29"},"publish_date":"2019-01-29","publish_status":"0","recid":"342","relation_version_is_last":true,"title":["SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:27.293345+00:00"}