{"created":"2023-05-15T09:41:16.251787+00:00","id":348,"links":{},"metadata":{"_buckets":{"deposit":"39f2d159-9a2b-431b-8741-9e1b653ebdf5"},"_deposit":{"created_by":11,"id":"348","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"348"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000348","sets":["13:40"]},"author_link":["2133"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-06-25"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nThe aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near‐infrared time‐resolved spectroscopy (TRS) and pathological change of the brain in a hypoxic‐ischemic (HI) piglet model.\nTwenty‐one anesthetized newborn piglets, including three sham controls, were studied. An HI event was induced by low inspired oxygen. CBV was measured using TRS (Hamamatsu TRS‐10). Data were collected before, during, and 6 h after the insult. CBV was calculated as the change from the end of the insult. The piglets were allowed to recover from anesthesia for 6 h after the insult. At the age of 5 days, the brains of the piglets were perfusion‐fixed, and histologic evaluations of brain tissue were performed. The extent of histopathological damage was graded in 0.5‐unit intervals on a 9‐step scale.\nCBV increments were well correlated with histopathological scores, especially at 1 and 3 h after resuscitation. Spearman's rank‐correlation coefficients at 1, 3, and 6 h after resuscitation in the gray matter were 0.9016, 0.9127, and 0.6907, respectively.\nWe conclude that an increased CBV after HI insult indicates more marked histological brain damage. CBV measurement immediately after resuscitation provides a more precise prediction of the histological outcome.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第613号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ijdevneu.2015.02.009","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11278721","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25702525","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001345113","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015 ISDN","subitem_rights_language":"en"},{"subitem_rights":"この博士論文の本文については、次のエルゼビアの著作権ポリシーの規定により公開しています。「博士論文の場合は、エンバーゴ期間に関係なく機関リポジトリに出版社版を公開することができます。」","subitem_rights_language":"ja"},{"subitem_rights":"The text of this doctoral dissertation is published according to the following Elsevier copyright policy. \"In the case of doctoral dissertations, publishers can be published in institutional repositories regardless of the Embargo period.\"","subitem_rights_language":"en"},{"subitem_rights":"Copyright © 2015 Elsevier Ltd. All rights reserved.","subitem_rights_language":"en"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"28613"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Nakamura, Makoto","creatorNameLang":"en"},{"creatorName":"中村, 信","creatorNameLang":"ja"},{"creatorName":"ナカムラ, マコト","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A613.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/348/files/Med_A613.pdf"},"version_id":"e1da963a-f749-4dde-b70d-2ac63acec8fa"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A613_abstract.pdf","filesize":[{"value":"166.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/348/files/Med_A613_abstract.pdf"},"version_id":"564a4f91-846f-47cf-9eb0-46575d5d9695"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-05"}],"displaytype":"detail","filename":"Med_A613_result.pdf","filesize":[{"value":"124.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/348/files/Med_A613_result.pdf"},"version_id":"24e18e72-0b79-4091-81ab-2e705a67023c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amplitude‐integrated electroencephalography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Animal model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain histology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral blood volume","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Near‐infrared spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypoxia‐ischemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-03-22"},"publish_date":"2019-03-22","publish_status":"0","recid":"348","relation_version_is_last":true,"title":["Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-02-07T08:32:19.257610+00:00"}