{"created":"2023-05-15T09:41:19.243458+00:00","id":421,"links":{},"metadata":{"_buckets":{"deposit":"8b33e2c4-b4d2-458f-b650-c8766c59354c"},"_deposit":{"created_by":11,"id":"421","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"421"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00000421","sets":["13:40"]},"author_link":["649"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: This study aimed to clarify the frequency of distal spread and the optimal distal margin after preoperative chemotherapy for advanced low rectal cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: The study included patients with advanced lower rectal cancer who received preoperative chemotherapy and underwent surgery during 2012-2015. We investigated the distal spread of tumor cells, defined as the distal distance from the intramucosal distal tumor edge to the farthest tumor cells located under the submucosal layer. Clinical characteristics were compared for distal spreads ≥ 10 and < 10 mm, and risk factors for distal spread ≥ 10 mm were investigated.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Of the 71 patients, 42 (59%) showed distal spread. Distal spreads of 1-9, 10-19, and ≥ 20 mm were observed in 27 (38%), 11 (15%), and 4 (6%) patients, respectively. Multivariate analysis revealed two independent risk factors for distal spread ≥ 10 mm after preoperative chemotherapy. The first risk factor is the presence of different therapeutic effects between the mucosal and deeper layers (meaning that superficial tumor shrinkage was evident on colonoscopy, but little tumor shrinkage was evident on magnetic resonance imaging) (odds ratio, 11.6; 95% CI, 2.22-61.3). The second risk factor is poorly differentiated or mucinous adenocarcinoma (odds ratio, 8.86; 95% CI, 1.58-49.9).","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: A distal margin of 20 mm is required (10 mm is insufficient) for advanced lower rectal cancer patients who receive preoperative chemotherapy followed by surgery. Independent risk factors for distal spread ≥ 10 mm include (1) the presence of different therapeutic effects between mucosal and deeper layers and (2) poorly differentiated or mucinous adenocarcinomas.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第734号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00384-018-3159-7","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://dl.ndl.go.jp/pid/11498630","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30215109","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"500001381061","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.","subitem_rights_language":"en"},{"subitem_rights":"エンバーゴ期間満了。 / The embargo period has expired.","subitem_rights_language":"ja"},{"subitem_rights":"出版社の著作権ポリシーにより、Accepted Versionを掲載する。","subitem_rights_language":"ja"}]},"item_10006_text_30":{"attribute_name":"KEID","attribute_value_mlt":[{"subitem_text_value":"28974"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kondo, Akihiro","creatorNameLang":"en"},{"creatorName":"近藤, 彰宏","creatorNameLang":"ja"},{"creatorName":"コンドウ, アキヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Kondo","familyNameLang":"en"},{"familyName":"近藤","familyNameLang":"ja"},{"familyName":"コンドウ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Akihiro","givenNameLang":"en"},{"givenName":"彰宏","givenNameLang":"ja"},{"givenName":"アキヒロ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"649","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000242803034 ","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000242803034 "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-11-10"}],"displaytype":"detail","filename":"Med_A734(Accepted Version).pdf","filesize":[{"value":"3.0 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/421/files/Med_A734_result.pdf"},"version_id":"17d275da-0349-4b7e-9335-4cd94320152c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Distal spread","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Distal margin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effect of preoperative chemotherapy on distal spread of low rectal cancer located close to the anus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of preoperative chemotherapy on distal spread of low rectal cancer located close to the anus","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-05-26"},"publish_date":"2020-05-26","publish_status":"0","recid":"421","relation_version_is_last":true,"title":["Effect of preoperative chemotherapy on distal spread of low rectal cancer located close to the anus"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T07:59:48.753847+00:00"}