{"created":"2023-05-15T09:45:59.388344+00:00","id":7336,"links":{},"metadata":{"_buckets":{"deposit":"edf9b186-2cee-4034-8cc5-135c31a1e72e"},"_deposit":{"created_by":11,"id":"7336","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"7336"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00007336","sets":["13:40"]},"author_link":["3207"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"グアーガム分解物による大量小腸切除後の小腸粘膜損傷の修復と腸内細菌叢の変化","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Short bowel syndrome is associated with intestinal mucosal inflammation and microbial dysbiosis, leading to intractable complications. Partially hydrolyzed guar gum (PHGG) has trophic and anti-inflammatory effects on the intestine. We investigated whether PHGG ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Methods: Sprague Dawley rats were divided into sham operation (Sham), Sham/PHGG, SBR, and SBR/PHGG groups. On day 21, all rats were euthanized. To assess small intestinal mucosal damage, the degeneration rate was morphometrically evaluated and immunohistochemically examined using anti-CD45 antibodies. Analyses of fecal microbiota using 16S rRNA and short-chain fatty acid production were also performed.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: The mucosal degeneration rate was significantly higher in the SBR group than in the Sham or SBR/PHGG groups. The number of CD45-positive cells was significantly higher in the SBR group than in the Sham, Sham/PHGG, or SBR/PHGG groups. The relative abundance of family Lachnospiraceae was significantly higher in the SBR/PHGG group than in the SBR group.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions: PHGG administration alleviated small intestinal mucosal damage which could be associated with modulation of the intestinal microbiota.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第770号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jpedsurg.2019.08.048","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31515113","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 Published by Elsevier Inc. ","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Fujii, Takayuki","creatorNameLang":"en"},{"creatorName":"藤井, 喬之","creatorNameLang":"ja"},{"creatorName":"フジイ, タカユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Fujii","familyNameLang":"en"},{"familyName":"藤井","familyNameLang":"ja"},{"familyName":"フジイ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Takayuki","givenNameLang":"en"},{"givenName":"喬之","givenNameLang":"ja"},{"givenName":"タカユキ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3207","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000018732132","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000018732132"},{"nameIdentifier":"00746696","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00746696"},{"nameIdentifier":"7000007636","nameIdentifierScheme":"researchmap","nameIdentifierURI":"https://researchmap.jp/7000007636"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A770.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/7336/files/Med_A770.pdf"},"version_id":"25b60b1a-50ea-462d-bea6-def57205a015"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A770_abstract.pdf","filesize":[{"value":"914.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/7336/files/Med_A770_abstract.pdf"},"version_id":"6f5faee8-7176-43ec-b9e4-22168b19a377"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A770_result.pdf","filesize":[{"value":"89.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/7336/files/Med_A770_result.pdf"},"version_id":"8a167828-3cda-4bec-b307-ee13ed4e4618"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Partially hydrolyzed guar gum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dietary fiber","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Short bowel syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Intestinal failure","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dysbosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Short chain fatty acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"7336","relation_version_is_last":true,"title":["Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:00:10.213365+00:00"}