{"created":"2023-05-15T09:45:59.431245+00:00","id":7337,"links":{},"metadata":{"_buckets":{"deposit":"946dff75-c581-4e08-8fa7-17e1453a7e04"},"_deposit":{"created_by":11,"id":"7337","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"7337"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00007337","sets":["13:40"]},"author_link":["3208"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"降圧薬であるテルミサルタンは生体内と試験管内において胃癌細胞の増殖を抑制する","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gastric cancer is one of the most common malignancies diagnosed worldwide. Telmisartan, an angiotensin receptor blocker (ARB), suppresses the proliferation of cancer cells and the growth of tumors through an unknown mechanism. To identify the mechanism, the present study was designed to evaluate the effects of telmisartan on gastric cancer cell lines and tumors in vitro and in vivo and the associated signaling molecules were identified. It was shown here that telmisartan suppressed the proliferation of the cultured human gastric cancer cell lines MKN74, MKN1 and MKN45 as detected in the CCK‑8 assay. In a mouse xenograft model of gastric cancer, telmisartan suppressed tumor growth by arresting the cell cycle at the G0/G1 phase through inhibition of the expression of cyclin D1, the catalytic subunit of cyclin dependent kinase 4 (CDK4), as well as the phosphorylation of the tumor suppressor retinoblastoma (pRb) protein as detected by western blotting. Notably, telmisartan did not induce apoptosis, as indicated by consistent levels of caspase‑cleaved keratin 18 in MKN74 cells. Furthermore, telmisartan inhibited the phosphorylation of epidermal growth factor receptor (EGFR) and increased the levels of the angiogenesis‑related protein tissue inhibitor of metalloproteinase‑1 (TIMP‑1). Analyses of microarrays revealed that telmisartan altered the expression of miRNAs in MKN74 cells. In conclusion, telmisartan suppressed the proliferation of human gastric cancer cells by inducing cell cycle arrest.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第771号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/or.2020.7607","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32627043","subitem_relation_type_select":"PMID"}}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Fujita, Naoki","creatorNameLang":"en"},{"creatorName":"藤田, 直樹","creatorNameLang":"ja"},{"creatorName":"フジタ, ナオキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A771.pdf","filesize":[{"value":"5.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/7337/files/Med_A771.pdf"},"version_id":"69025cb0-5ca7-4e16-ac97-f4c20cd5f7b6"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A771_abstract.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/7337/files/Med_A771_abstract.pdf"},"version_id":"fe07e7e9-494c-4a89-ac04-0534dca18e3b"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"displaytype":"detail","filename":"Med_A771_result.pdf","filesize":[{"value":"151.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/7337/files/Med_A771_result.pdf"},"version_id":"984c3695-7593-40e4-a080-b369be2cb535"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Line, Tumor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell Survival","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin D1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin-Dependent Kinase 4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Repositioning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene Expression Regulation, Neoplastic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MicroRNAs","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphorylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Retinoblastoma Protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Stomach Neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Telmisartan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Xenograft Model Antitumor Assays","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells in vitro and in vivo.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells in vitro and in vivo.","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"7337","relation_version_is_last":true,"title":["Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells in vitro and in vivo."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-02-09T01:29:53.081896+00:00"}