{"created":"2023-05-15T09:45:59.684234+00:00","id":7343,"links":{},"metadata":{"_buckets":{"deposit":"bc64e4f0-82bd-4ac6-95b0-b9447af1704d"},"_deposit":{"created_by":11,"id":"7343","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"7343"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00007343","sets":["13:40"]},"author_link":["3214"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"膵癌細胞へのテルミサルタン投与におけるMicroRNA発現プロファイル","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-03-24"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Panereatic ductal adenocarcinoma (PDAC) is the most devastating of all cancers with an extremely poor prognosis. It has few effective and reliable therapeutic strategies. Telmisartan, a widely used antihypertensive drug, is an angiotensin II type 1 (AT1) receptor blocker (ARB). Telmisartan inhibits cancer cell proliferation, but the underlying mechanisms in PDAC, remain unknown.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Material and Methods: In the present study, we evaluated the effects of telmisartan on human PDAC cell proliferation in vitro. We assessed the effects of telmisartan on human PDAC cells using the cell lines PK-1 and PANC-1.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Results: Tel misartan inhibited the proliferation of these cells via blockade of the GO to G1 cell cycle transition. This was accompanied by a strong decrease in cyclin 01. Telmisartan was also shown by receptor tyrosine kinase and angiogenesis arrays to reduce the phosphorylation of epidermal growth factor receptor (EGFR), and miRNA expression was markedly altered by telmisartan in PK-1 cells.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: In conclusion, telmisartan inhibits human PDAC cell proliferation by inducing cell cycle arrest. Furthermore, telmisartan significantly altered miRNA expression in vitro. Taken together, our study demonstrated the therapeutic potential of telmisartan and provides molecular mechanistic insights into its anti-tumor effect on PDAC cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第777号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4103/jcrt.jcrt_104_20","subitem_relation_type_select":"DOI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"36510981","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer – Medknow","subitem_rights_language":"en"},{"subitem_rights":"This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.","subitem_rights_language":"en","subitem_rights_resource":"https://creativecommons.org/licenses/by-nc-sa/4.0/"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamana, Yoshimi","creatorNameLang":"en"},{"creatorName":"山名, 佳美","creatorNameLang":"ja"},{"creatorName":"ヤマナ, ヨシミ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Yamana","familyNameLang":"en"},{"familyName":"山名","familyNameLang":"ja"},{"familyName":"ヤマナ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yoshimi","givenNameLang":"en"},{"givenName":"佳美","givenNameLang":"ja"},{"givenName":"ヨシミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3214","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-22"}],"filename":"Med_A777.pdf","filesize":[{"value":"4.2 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/7343/files/Med_A777_result.pdf"},"version_id":"d692a4ef-5a0d-485c-b632-473e9a435095"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Angiotensin II type 1 receptor blocker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle arrest","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic ductal adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"telmisartan","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-22"},"publish_date":"2021-04-22","publish_status":"0","recid":"7343","relation_version_is_last":true,"title":["MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-10-31T08:01:36.503620+00:00"}