{"created":"2023-05-15T09:46:02.930133+00:00","id":7450,"links":{},"metadata":{"_buckets":{"deposit":"5fd58b6f-f03b-4a96-ab19-8b8711da5b7d"},"_deposit":{"created_by":11,"id":"7450","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"7450"},"status":"published"},"_oai":{"id":"oai:kagawa-u.repo.nii.ac.jp:00007450","sets":["13:40"]},"author_link":["2470"],"item_10006_alternative_title_1":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"緑色発光ダイオード下でのビリルビン光化学反応の特徴 :ヒトと動物種間での比較検討","subitem_alternative_title_language":"ja"}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-06-29"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"香川大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Kagawa University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"16201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that centered on the blue spectrum for neonatal hyperbilirubinemia. There are no reports of species differences in bilirubin photochemical changes in this spectrum, and the characteristics of bilirubin photochemical changes in humans must be elucidated to proceed with the development of new light sources that include these spectra. This report describes the characteristic photochemical kinetics of bilirubin under green-spectrum LEDs in human, rat, rabbit, dog, pig, sheep, bovine and chicken serum albumin and rhesus monkey serum. These albumin-bilirubin complex solutions were irradiated by green LEDs, and the time-course changes in bilirubin photoisomers were measured by high-performance liquid chromatography. The cyclobilirubin production rates in humans, pigs, and monkeys were significantly higher than those in other species. The rate constant of (EZ)-cyclobilirubin production from (EZ)-bilirubin ‘k’ was significantly higher in humans and monkeys than in other species. In conclusion, bilirubin photochemical kinetics under green spectrum LEDs in humans were characterized by a high cyclobilirubin production rate at a low substrate concentration. The bilirubin photochemical kinetics in monkeys were similar to those in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第780号"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-021-85632-5","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"hasVersion","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7973762/","subitem_relation_type_select":"URI"}}]},"item_10006_relation_22":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33737608","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2021, The Author(s)","subitem_rights_language":"en"},{"subitem_rights":"Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"},{"subitem_rights":"No Embargo","subitem_rights_language":"en"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_fa2ee174bc00049f","subitem_version_type":"P"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新居, 広一郎","creatorNameLang":"ja"},{"creatorName":"ニイ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Nii, Kohichiroh","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-13"}],"displaytype":"detail","filename":"Med_A780.pdf","filesize":[{"value":"351.4 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://kagawa-u.repo.nii.ac.jp/record/7450/files/Med_A780.pdf"},"version_id":"ee20f4b9-b2fc-4db4-9893-e6e4711e1a09"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-13"}],"displaytype":"detail","filename":"Med_A780_abstract.pdf","filesize":[{"value":"104.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容の要旨","objectType":"abstract","url":"https://kagawa-u.repo.nii.ac.jp/record/7450/files/Med_A780_abstract.pdf"},"version_id":"f4705f19-e9e6-467d-8cad-55562537cc64"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-13"}],"displaytype":"detail","filename":"Med_A780_result.pdf","filesize":[{"value":"127.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査の結果の要旨","objectType":"other","url":"https://kagawa-u.repo.nii.ac.jp/record/7450/files/Med_A780_result.pdf"},"version_id":"231d0531-a9c4-429d-86ac-555dd25cee25"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemical biology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biophysical chemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Experimental models of disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Paediatric research","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lasers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LEDs and light sources","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"11","path":["40"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-13"},"publish_date":"2021-07-13","publish_status":"0","recid":"7450","relation_version_is_last":true,"title":["Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-10-16T02:30:27.357648+00:00"}